From the Department of Neurology and China-America Institute of Neuroscience (D.W., L.W., J.C., X.H., Y.D., X.J.), Xuanwu Hospital, Capital Medical University, Beijing.
Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI (M.H.).
Stroke. 2020 May;51(5):1620-1623. doi: 10.1161/STROKEAHA.119.028108. Epub 2020 Apr 1.
Background and Purpose- Nonhuman primates are increasingly used in translational studies of ischemic stroke. However, current scoring systems in monkeys (eg, Nonhuman Primate Stroke Scale) do not focus on impairments in activities of daily living, so clinically relevant data are scarce for evaluating functional deficits in this model. Methods- Here, we referenced the modified Rankin Scale to provide a primate version of Rankin Scale (pRS) for ranking neurological dysfunction in monkeys following stroke. We selected hand function and strength, level of activity, and general mobility as the main components of pRS. We also analyzed interobserver variability. Results- pRS is a simple scale with only 6 levels. Functional deficit can be easily classified into none (category 0), slight (categories 1-2), moderate (category 3-4), and severe disabilities (category 5) based on pRS. We validated this scoring system on 11 monkeys, all with varying levels of neurological dysfunction following stroke, assessed by blinded testers. After a short training period, both technicians and neurology residents were able to achieve a high level of consistency using this scoring system. Conclusions- pRS is a simple and reliable functional scale, similar to the widely used modified Rankin Scale, for evaluating long-term neurological dysfunction in nonhuman primates. We recommend further validation studies and analyses.
背景与目的- 非人类灵长类动物越来越多地用于缺血性中风的转化研究。然而，猴子目前的评分系统（如非人类灵长类动物中风量表）并不关注日常生活活动中的损伤，因此缺乏评估该模型功能缺陷的临床相关数据。方法- 在这里，我们参考改良的兰金量表（modified Rankin Scale），为猴子中风后神经功能障碍提供了灵长类版本的兰金量表（primate version of Rankin Scale，pRS）。我们选择手功能和力量、活动水平和一般活动能力作为 pRS 的主要组成部分。我们还分析了观察者间的变异性。结果- pRS 是一个只有 6 个级别的简单量表。根据 pRS，功能缺陷可以很容易地分为无缺陷（类别 0）、轻度缺陷（类别 1-2）、中度缺陷（类别 3-4）和严重残疾（类别 5）。我们通过 11 只猴子验证了这一评分系统，这些猴子在中风后都有不同程度的神经功能障碍，由盲法测试者进行评估。经过短暂的培训期，技术人员和神经科住院医师都能够使用该评分系统达到高度一致的水平。结论- pRS 是一种简单可靠的功能量表，类似于广泛使用的改良兰金量表，用于评估非人类灵长类动物的长期神经功能障碍。我们建议进一步进行验证研究和分析。
