Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
School of Medicine, Queen's University, Kingston, ON, Canada.
Nat Commun. 2024 Oct 18;15(1):9005. doi: 10.1038/s41467-024-53365-4.
Stroke, a major cause of disability, disrupts brain function and motor skills. Previous research has mainly focused on reorganization of the motor system post-stroke, but the effects on other brain areas and their influence on recovery is poorly understood. Here, we use functional neuroimaging in a nonhuman primate model (23 male Cynomolgus Macaques), we explore how ischemic stroke affects whole-brain cortical architecture and its relation to spontaneous behavioral recovery. By projecting patterns of cortical functional connectivity onto a low-dimensional manifold space, we find that several regions in both sensorimotor cortex and higher-order transmodal cortex exhibit significant shifts in their manifold embedding from pre- to post-stroke. Furthermore, we observe that changes in default mode and limbic network regions, and not preserved sensorimotor cortical regions, are associated with animal behavioral recovery post-stroke. These results establish the whole-brain functional changes associated with stroke, and suggest an important role for higher-order transmodal cortex in post-stroke outcomes.
中风是导致残疾的主要原因，它会破坏大脑功能和运动技能。以前的研究主要集中在中风后运动系统的重组，但对其他大脑区域的影响及其对恢复的影响知之甚少。在这里，我们使用功能神经影像学在非人类灵长类动物模型（23 只雄性恒河猴）中，我们探讨了缺血性中风如何影响全脑皮质结构及其与自发性行为恢复的关系。通过将皮质功能连接模式投射到低维流形空间上，我们发现从中风前到中风后，感觉运动皮层和更高阶跨模态皮层中的几个区域在流形嵌入中都发生了显著变化。此外，我们观察到默认模式和边缘网络区域的变化，而不是保留的感觉运动皮层区域，与中风后动物行为恢复有关。这些结果确定了与中风相关的全脑功能变化，并表明高阶跨模态皮层在中风后的结果中起着重要作用。
