Goehner Schweizer Katja, Maurer Britta
Klinik für Rheumatologie Universitätsspital Zürich.
Praxis (Bern 1994). 2020;109(5):341-345. doi: 10.1024/1661-8157/a003443.
New and Established Therapeutic Options for the Treatment of Systemic Lupus Erythematosus Systemic lupus erythematosus is a multisystem autoimmune disease. The mainstay of therapy are antimalarials, mostly hydroxychloroquine, which should be given whenever possible. Belimumab is in the meantime a well-established add-on treatment. In the first place, joint manifestations as well as skin and fatigue improve. It was also shown to reduce severe flares and steroid use. Another therapeutic option in the future might be the interferon anifrolumab due to positive results in new studies. In case of renal manifestations mycophenolate mofetil is widely used.
系统性红斑狼疮治疗的新的和已有的治疗选择 系统性红斑狼疮是一种多系统自身免疫性疾病。治疗的主要药物是抗疟药，大多是羟氯喹，应尽可能使用。与此同时，贝利尤单抗是一种成熟的附加治疗药物。首先，关节表现以及皮肤症状和疲劳会有所改善。它还被证明可减少严重发作和类固醇的使用。由于新研究取得了积极成果，未来另一种治疗选择可能是干扰素阿尼氟单抗。对于肾脏表现，霉酚酸酯被广泛使用。
