Division of Dental Anesthesiology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
Division of Physiology, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.
J Physiol Sci. 2020 Mar 31;70(1):22. doi: 10.1186/s12576-020-00749-y.
The skin temperature (T) of the orofacial area influences orofacial functions and is related to the blood flow (BF). Marked increases in BF mediated by parasympathetic vasodilation may be important for orofacial T regulation. Therefore, we examined the relationship between parasympathetic reflex vasodilation and orofacial T in anesthetized rats. Electrical stimulation of the central cut end of the lingual nerve (LN) elicited significant increases in BF and T in the lower lip. These increases were significantly reduced by hexamethonium, but not atropine. VIP agonist increased both BF and T in the lower lip. The activation of the superior cervical sympathetic trunk (CST) decreased BF and T in the lower lip; however, these decreases were significantly inhibited by LN stimulation. Our results suggest that parasympathetic vasodilation plays an important role in the maintaining the hemodynamics and T in the orofacial area, and that VIP may be involved in this response.
口腔面部区域的皮肤温度（T）会影响口腔面部功能，并与血流量（BF）有关。迷走神经介导的 BF 显著增加可能对口腔 T 调节很重要。因此，我们在麻醉大鼠中检查了副交感反射性血管扩张与口腔 T 之间的关系。舌神经（LN）中枢切断端的电刺激引起下唇 BF 和 T 的显著增加。这些增加被六甲铵显著降低，但阿托品不能。VIP 激动剂增加下唇的 BF 和 T。颈上交感干（CST）的激活降低下唇的 BF 和 T；然而，LN 刺激显著抑制了这些降低。我们的结果表明，副交感神经血管舒张在维持口腔面部区域的血液动力学和 T 中起重要作用，并且 VIP 可能参与了这种反应。
