Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC), Gran Via Carles III, 85 bis, 08028, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Alzheimers Res Ther. 2020 Mar 31;12(1):37. doi: 10.1186/s13195-020-00602-9.
Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-β (Aβ) uptake.
We investigated the association of retinal thickness quantified by OCT with Aβ accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD.
One hundred twenty-nine individuals with SCD enrolled in Fundació ACE Healthy Brain Initiative underwent comprehensive neuropsychological testing, OCT scan of the retina and florbetaben (FBB) positron emission tomography (PET) at baseline (v0) and after 24 months (v2). We assessed the association of sixteen retinal thickness measurements at baseline with FBB-PET status (+/-) and global standardize uptake value ratio (SUVR) as a continuous measure at v0 and v2 and their predictive value on clinical status change (conversion to mild cognitive impairment (MCI)) at v2.
Mean age of the sample was 64.72 ± 7.27 years; 62.8% were females. Fifteen participants were classified as FBB-PET+ at baseline and 22 at v2. Every 1 μm of increased thickness in the inner nasal macular region conferred 8% and 6% higher probability of presenting a FBB-PET+ status at v0 (OR = 1.08, 95% CI = 1.02-1.14, p = 0.007) and v2 (OR = 1.06, 95% CI = 1.02-1.11, p = 0.004), respectively. Inner nasal macular thickness also positively correlated with global SUVR (at v0: β = 0.23, p = 0.004; at v2: β = 0.26, p = 0.001). No retinal measurements were associated to conversion to MCI over 24 months.
Subtle retinal thickness changes in the macular region are already present in SCD and correlate with Aβ uptake.
视网膜光学相干断层扫描（OCT）是一种快速且易于获取的工具，可用于量化视网膜结构测量值。多项研究表明，与年龄匹配的对照组相比，阿尔茨海默病（AD）患者的多个视网膜层变薄。主观认知下降（SCD）已被提议作为进展为 AD 的风险因素。关于临床前 AD 中的视网膜变化及其与淀粉样蛋白-β（Aβ）摄取的相关性，数据很少。
我们研究了在 SCD 个体中，通过 OCT 定量的视网膜厚度与 Aβ 积聚以及在 24 个月内转化为轻度认知障碍（MCI）之间的相关性。
129 名患有 SCD 的个体参加了 Fundació ACE Healthy Brain Initiative，他们在基线（v0）和 24 个月后（v2）接受了全面的神经心理学测试、视网膜 OCT 扫描和 florbetaben（FBB）正电子发射断层扫描（PET）。我们评估了基线时 16 项视网膜厚度测量值与 FBB-PET 状态（+/-）和全局标准化摄取值比（SUVR）作为 v0 和 v2 的连续测量值之间的相关性，以及它们在 v2 时临床状态变化（转化为轻度认知障碍（MCI））的预测值。
样本的平均年龄为 64.72±7.27 岁；62.8%为女性。15 名参与者在基线时被归类为 FBB-PET+，22 名参与者在 v2 时被归类为 FBB-PET+。内鼻黄斑区每增加 1μm 的厚度，v0 时出现 FBB-PET+状态的可能性就会增加 8%（OR=1.08，95%CI=1.02-1.14，p=0.007），v2 时的可能性就会增加 6%（OR=1.06，95%CI=1.02-1.11，p=0.004）。内鼻黄斑厚度也与全局 SUVR 呈正相关（v0：β=0.23，p=0.004；v2：β=0.26，p=0.001）。在 24 个月内，没有视网膜测量值与向 MCI 的转化相关。
在 SCD 中已经存在黄斑区细微的视网膜厚度变化，并且与 Aβ 摄取相关。
