环状 RNA 在阿尔茨海默病中的功能作用。

Functional roles of circular RNAs in Alzheimer's disease.

机构信息

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China; Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.

出版信息

Ageing Res Rev. 2020 Jul;60:101058. doi: 10.1016/j.arr.2020.101058. Epub 2020 Mar 29.

DOI:10.1016/j.arr.2020.101058

PMID:32234545

Abstract

Although efforts have been made to develop therapeutic approaches, the clinical management of AD maintains a major challenge. CircRNAs are highly abundant and evolutionarily conserved in neuronal tissues in mammals. Accumulating data suggest that circRNAs regulate biological and pathological processes by sponging miRNAs, binding to RBPs, modulating mRNA stability, and being translated into peptides in various diseases, serving as biomarkers and potential therapeutic targets. Growing evidence demonstrates that circRNAs have been implicated in the pathogenesis of AD. Here, we summarized current studies on circRNAs involved in AD pathology, providing a theoretical basis for the use of circRNAs in AD treatment and diagnosis.

摘要

虽然已经努力开发治疗方法，但 AD 的临床管理仍然是一个主要挑战。CircRNAs 在哺乳动物的神经元组织中高度丰富且进化上保守。越来越多的证据表明，CircRNAs 通过海绵 miRNA、结合 RBPs、调节 mRNA 稳定性以及在各种疾病中翻译为肽来调节生物学和病理过程，作为生物标志物和潜在的治疗靶点。越来越多的证据表明，CircRNAs 与 AD 的发病机制有关。在这里，我们总结了涉及 AD 病理学的 CircRNAs 的当前研究，为 CircRNAs 在 AD 治疗和诊断中的应用提供了理论依据。