二甲基砜对 A549 肺癌细胞增殖和凋亡的影响：通过 G/M 细胞周期阻滞和内在细胞死亡途径。
Effect of Methylsulfonylmethane on Proliferation and Apoptosis of A549 Lung Cancer Cells Through G/M Cell-cycle Arrest and Intrinsic Cell Death Pathway.
机构信息
Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea
出版信息
Anticancer Res. 2020 Apr;40(4):1905-1913. doi: 10.21873/anticanres.14145.
BACKGROUND/AIM: Methylsulfonylmethane (MSM) is a natural organic compound that displays anti-inflammatory as well as antioxidant properties. MSM reportedly has potential in inhibition of tumor cells. However, molecular mechanisms underlying the effects of MSM on lung cancer remain unclear.
MATERIALS AND METHODS
In this study, the effect of MSM on A549 cells was examined. We focused on the mode of apoptosis induced by MSM and investigated alterations in the integrity of the outer membrane of mitochondria.
RESULTS
Our results showed that MSM inhibited viability of A549 cells and changed the shape and permeability of nuclei. In addition, MSM induced G/M arrest. MSM reduced the mitochondrial membrane potential and contributed to release of cytochrome c from mitochondria to cytoplasm.
CONCLUSION
MSM is a potential anticancer agent for the treatment of lung cancer.
背景/目的：二甲砜（MSM）是一种天然有机化合物，具有抗炎和抗氧化特性。据报道，MSM 具有抑制肿瘤细胞的潜力。然而，MSM 对肺癌影响的分子机制尚不清楚。
材料与方法
在这项研究中，研究了 MSM 对 A549 细胞的作用。我们专注于 MSM 诱导细胞凋亡的方式，并研究了线粒体外膜完整性的变化。
结果
我们的结果表明，MSM 抑制了 A549 细胞的活力并改变了细胞核的形状和通透性。此外，MSM 诱导了 G/M 期阻滞。MSM 降低了线粒体膜电位，并导致细胞色素 c 从线粒体释放到细胞质中。
结论
MSM 是治疗肺癌的一种有潜力的抗癌药物。
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