眼附属器淋巴组织增生性疾病中细胞表面标志物 CD38 和 CD138 的改变。

Alteration of Cell Surface Markers CD38 and CD138 in Lymphoproliferative Disorders in the Ocular Adnexa.

机构信息

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

出版信息

Anticancer Res. 2020 Apr;40(4):2019-2023. doi: 10.21873/anticanres.14158.

DOI:10.21873/anticanres.14158

PMID:32234892

Abstract

BACKGROUND/AIM: CD38 is a cell surface marker commonly present in plasma cells and activated T cells, while CD138 is a representative plasma cell marker. The aim of this study was to describe the expression of cell surface markers including CD38 and CD138, in the tumors of patients with IgG4-related ophthalmic disease (IgG4-ROD) and extranodal marginal zone B-cell lymphoma (EMZL) of the ocular adnexa.

MATERIALS AND METHODS

Twenty-four consecutive patients of whom 12 had IgG4-ROD and 12 EMZL were enrolled in this study. Medical records were reviewed for flow cytometry (FCM) results on conventional T-cell markers, B-cell markers, CD38 and CD138.

RESULTS

Positive rates of T-cell markers, CD38 and CD138 were significantly higher in IgG4-ROD than in EMZL (p<0.01 and p<0.05, respectively).

CONCLUSION

Our FCM results on CD38 and CD138 showed that the lymphocyte populations were different between IgG4-ROD and EMZL, which may reflect the different pathophysiology of the two diseases.

摘要

背景/目的：CD38 是一种常见于浆细胞和活化 T 细胞表面的标志物，而 CD138 是浆细胞的代表性标志物。本研究旨在描述 IgG4 相关眼病（IgG4-ROD）和眶外淋巴结边缘区 B 细胞淋巴瘤（EMZL）患者肿瘤中细胞表面标志物包括 CD38 和 CD138 的表达情况。