肺腺癌外显子组文件中的 B 细胞受体重组与更高的总生存率相关。
B-cell Receptor Recombinations in Lung Adenocarcinoma Exome Files Correlate With a Higher Overall Survival Rate.
机构信息
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A.
出版信息
Anticancer Res. 2020 Apr;40(4):2043-2051. doi: 10.21873/anticanres.14161.
BACKGROUND/AIM: While there has been a rapid development in genomic data mining approaches for T-cell receptor recombinations (TcR), less emphasis has been placed on B-cell receptor (BcR) recombinations.
MATERIALS AND METHODS
We obtained lung cancer exome files from the cancer genome atlas (TCGA) and mined the files for TcR and BcR recombination reads.
RESULTS
There was a robust detection of BcR light chain recombination reads in lung adenocarcinoma (TCGA-LUAD) samples, and there was a correlation between the detection of light chain recombination reads and a more favorable outcome. This result was supported by analyses of the expression of B-cell markers as indicated by LUAD RNASeq files.
CONCLUSION
BcR and TcR recombination reads recovered from LUAD WXS files, either alone or in combination with the human leukocyte antigen (HLA) type, are likely to have prognostic value.
背景/目的：虽然 T 细胞受体（TCR）重组的基因组数据挖掘方法已经取得了快速发展，但对 B 细胞受体（BCR）重组的重视程度较低。
材料和方法
我们从癌症基因组图谱（TCGA）获得了肺癌外显子组文件，并对文件中的 TCR 和 BCR 重组读取进行了挖掘。
结果
在肺腺癌（TCGA-LUAD）样本中，BCR 轻链重组读取得到了有力的检测，并且轻链重组读取的检测与更好的预后结果相关。这一结果得到了 LUAD RNAseq 文件中 B 细胞标志物表达分析的支持。
结论
从 LUAD WXS 文件中单独或与人类白细胞抗原（HLA）类型一起恢复的 BCR 和 TCR 重组读取，可能具有预后价值。
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