Breast Center Zurich, Zurich, Switzerland.
Institute of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland.
Anticancer Res. 2020 Apr;40(4):2125-2131. doi: 10.21873/anticanres.14171.
BACKGROUND/AIM: Triple-negative breast cancer (TNBC) can be divided into subtypes of basal-like (BL), mesenchymal-like (ML), luminal androgen receptor (LAR), and immunomodulatory (IM). The aim of our study was to assess whether there are distinct radiologic features within the different TNBC subtypes and whether this has potential clinical impact.
Imaging pictures of 135 patients with TNBC were re-evaluated. TNBC subtyping was performed on asservated tumor tissue using a panel of antibodies.
Mammographic margins of LAR-TNBC were more often spiculated (24.3% versus 0-4.1%). BL-TNBC presented more frequent a mass without calcification in mammogram than other subtypes (71.4% versus 48.6-57.9%). In ultrasound, ML and LAR were described more often with smooth borders.
The histopathological subtype of TNBC influences its presentation in ultrasound and mammogram. This can reflect a different growth pattern of the subtypes and may have an impact on the early diagnosis of TNBC.
背景/目的:三阴性乳腺癌(TNBC)可分为基底样(BL)、间质样(ML)、腔面雄激素受体(LAR)和免疫调节型(IM)亚型。本研究旨在评估不同 TNBC 亚型中是否存在独特的影像学特征,以及这是否具有潜在的临床影响。
对 135 例 TNBC 患者的影像学图片进行重新评估。使用一组抗体对保留的肿瘤组织进行 TNBC 亚型分型。
LAR-TNBC 的乳腺 X 线摄影边缘更常呈毛刺状(24.3%比 0-4.1%)。BL-TNBC 在乳腺 X 线摄影中比其他亚型更常出现无钙化的肿块(71.4%比 48.6-57.9%)。在超声中,ML 和 LAR 更常描述为边界光滑。
TNBC 的组织病理学亚型影响其在超声和乳腺 X 线摄影中的表现。这可能反映了亚型的不同生长模式,并可能对 TNBC 的早期诊断产生影响。