Brumec Maša, Sobočan Monika, Takač Iztok, Arko Darja
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia.
Department of Pharmacology, Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia.
Cancers (Basel). 2021 Apr 1;13(7):1642. doi: 10.3390/cancers13071642.
This review summarizes the recent findings of a vast array of studies conducted on androgen receptor-positive triple-negative breast cancer (AR-positive TNBC) to provide a better understanding of this specific breast cancer subgroup. AR expression is correlated with higher age, lower histological grade, lower proliferation index Ki-67, spiculated masses, and calcifications on mammography. Studies investigating the correlation between AR expression and lymph node metastasis are highly discordant. In addition, results regarding prognosis are highly contradictory. AR antagonists are a promising novel therapeutic approach in AR-positive TNBC. However, AR signaling pathways should be more investigated in order to understand the influence of AR expression on TNBC more thoroughly.
本综述总结了近期针对雄激素受体阳性三阴性乳腺癌（AR阳性TNBC）开展的大量研究结果，以便更好地了解这一特定的乳腺癌亚组。AR表达与较高年龄、较低组织学分级、较低增殖指数Ki-67、乳腺钼靶上的毛刺状肿块及钙化相关。研究AR表达与淋巴结转移之间相关性的结果差异很大。此外，关于预后的结果也存在高度矛盾。AR拮抗剂在AR阳性TNBC中是一种有前景的新型治疗方法。然而，为了更全面地了解AR表达对TNBC的影响，应进一步研究AR信号通路。
