不同乳腺癌亚型中 FOXP3/CD8 淋巴细胞比值与肿瘤浸润淋巴细胞水平的相关性研究。
Association Between FOXP3/CD8 Lymphocyte Ratios and Tumor Infiltrating Lymphocyte Levels in Different Breast Cancer Subtypes.
机构信息
Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Department of Surgical Pathology, Hyogo College of Medicine, Hyogo, Japan.
出版信息
Anticancer Res. 2020 Apr;40(4):2141-2150. doi: 10.21873/anticanres.14173.
BACKGROUND/AIM: Patients with non-luminal breast cancer subtypes with high levels of tumor infiltrating lymphocytes (TILs) have better prognosis than those with luminal subtype. We evaluated the role of TILs according to the subtype.
MATERIALS AND METHODS
An immunohistochemical analysis of 139 breast cancer cases was conducted to calculate the FOXP3+/CD8+ T cell ratios and their relationships with TILs and disease-free survival (DFS) were evaluated.
RESULTS
FOXP3+/CD8+ T cell ratios were significantly associated with TIL levels only in luminal breast cancers (p=0.0001). Low FOXP3+/CD8+ T cell ratio was significantly associated with longer DFS (p=0.017). All luminal subtype patients with high TIL levels had high FOXP3+/CD8+ T cell ratios compared to only half of non-luminal subtype patients with high TIL levels.
CONCLUSION
High FOXP3+/CD8+ T cell ratios in breast cancers may partly explain the worse prognosis of luminal breast cancers, but not that of non-luminal breast cancers with high TIL levels.
背景/目的：浸润性淋巴细胞（TILs）水平高的非腔面型乳腺癌亚型患者的预后优于腔面型乳腺癌亚型患者。我们根据亚型评估了 TILs 的作用。
材料和方法
对 139 例乳腺癌病例进行了免疫组化分析，计算了 FOXP3+/CD8+ T 细胞比值，并评估了其与 TILs 和无病生存（DFS）的关系。
结果
FOXP3+/CD8+ T 细胞比值仅与腔面型乳腺癌的 TIL 水平显著相关（p=0.0001）。低 FOXP3+/CD8+ T 细胞比值与较长的 DFS 显著相关（p=0.017）。所有 TIL 水平高的腔面型乳腺癌患者的 FOXP3+/CD8+ T 细胞比值均较高，而非 TIL 水平高的非腔面型乳腺癌患者中仅有一半的 FOXP3+/CD8+ T 细胞比值较高。
结论
乳腺癌中高 FOXP3+/CD8+ T 细胞比值可能部分解释了腔面型乳腺癌预后较差，但不能解释 TIL 水平高的非腔面型乳腺癌的预后。
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