Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Trends Cancer. 2022 Nov;8(11):944-961. doi: 10.1016/j.trecan.2022.06.008. Epub 2022 Jul 16.
The success of immunotherapy in oncology underscores the vital role of the immune system in cancer development. Regulatory T cells (Tregs) maintain a fine balance between autoimmunity and immune suppression. They have multiple roles in the tumor microenvironment (TME) but act particularly in suppressing T cell activation. This review focuses on the detrimental and sometimes beneficial roles of Tregs in tumors, our current understanding of recruitment and stabilization of Tregs within the TME, and current Treg-targeted therapeutics. Research identifying subpopulations of Tregs and their respective functions and interactions within the complex networks of the TME will be crucial to develop the next generation of immunotherapies. Through these advances, Treg-targeted immunotherapy could have important implications for the future of oncology.
免疫疗法在肿瘤学中的成功突出了免疫系统在癌症发展中的重要作用。调节性 T 细胞 (Tregs) 在自身免疫和免疫抑制之间保持着微妙的平衡。它们在肿瘤微环境 (TME) 中发挥多种作用，但特别作用是抑制 T 细胞的激活。本综述重点介绍 Tregs 在肿瘤中的有害和有时有益的作用、我们目前对 Tregs 在 TME 中的募集和稳定的理解，以及当前针对 Tregs 的治疗方法。确定 Tregs 的亚群及其在 TME 的复杂网络中的各自功能和相互作用的研究，对于开发下一代免疫疗法至关重要。通过这些进展，针对 Treg 的免疫疗法可能对肿瘤学的未来产生重要影响。
