Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
Anticancer Res. 2020 Apr;40(4):2275-2281. doi: 10.21873/anticanres.14192.
BACKGROUND/AIM: To assess the prognostic effect of muscle loss after esophagectomy and before discharge.
This study retrospectively analysed 159 consecutive patients with oesophageal and gastroesophageal junction cancer who underwent esophagectomy between August 2011 and October 2015. Body composition was evaluated one week before surgery and at discharge using a bioelectrical impedance analyser.
The median rate of muscle mass loss (RMML) was 4.38% (range=-3.3 to +18.8). Patients with increased RMML had significantly poorer outcomes of overall survival than those with decreased RMML (p=0.015). On multivariate analysis, RMML [≥4.38, hazard ratio (HR)=2.033, 95% confidence interval (CI)=1.018-5.924, p=0.044) and pathological tumour depth (≥2, HR=3.099, 95%CI=1.339-7.172, p=0.008) were selected as independent prognostic factors.
RMML after esophagectomy is indicative of poor prognosis in patients with esophageal cancer.
背景/目的：评估食管癌术后出院前肌肉损失的预后影响。
本研究回顾性分析了 2011 年 8 月至 2015 年 10 月期间接受食管癌和食管胃交界癌切除术的 159 例连续患者。在术前一周和出院时使用生物电阻抗分析仪评估身体成分。
肌肉质量损失（RMML）的中位数率为 4.38%（范围=-3.3 至+18.8）。RMML 增加的患者的总生存率明显低于 RMML 减少的患者（p=0.015）。多因素分析显示，RMML [≥4.38，风险比（HR）=2.033，95%置信区间（CI）=1.018-5.924，p=0.044]和病理肿瘤深度（≥2，HR=3.099，95%CI=1.339-7.172，p=0.008）是独立的预后因素。
食管癌术后 RMML 是预测食管癌患者预后不良的指标。
