First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
Anticancer Res. 2020 Apr;40(4):2311-2317. doi: 10.21873/anticanres.14197.
BACKGROUND/AIM: Elevated neutrophil-lymphocyte ratio (NLR) has been reported to be a poor prognostic factor in patients with colorectal cancer (CRC). However, no studies have focused on the dynamic change of preoperative NLR (pre-NLR) in CRC patients. We investigated the prognostic value of the change in NLR (ΔNLR) in CRC patients before and after surgery.
We retrospectively analyzed the data from 307 patients with stage II or III CRC. We compared the clinicopathological factors, OS, and DFS among the various NLR factors.
The 5-year OS rate of the high ΔNLR group was significantly lower than that of the low ΔNLR group (p<0.01). The 5-year DFS rates of the high ΔNLR groups were worse than those in the low ΔNLR groups. In the multivariate analysis, ΔNLR was an independent prognostic factor (p=0.011).
Decreasing post-NLR was related to better OS and DFS even in high pre-NLR patients with CRC.
背景/目的：中性粒细胞与淋巴细胞比值（NLR）升高已被报道为结直肠癌（CRC）患者的预后不良因素。然而，尚无研究关注 CRC 患者术前 NLR（pre-NLR）的动态变化。我们研究了手术前后 NLR（ΔNLR）变化对 CRC 患者的预后价值。
我们回顾性分析了 307 例 II 期或 III 期 CRC 患者的数据。我们比较了不同 NLR 因素的临床病理因素、OS 和 DFS。
高 ΔNLR 组的 5 年 OS 率明显低于低 ΔNLR 组（p<0.01）。高 ΔNLR 组的 5 年 DFS 率较低 ΔNLR 组差。多因素分析显示，ΔNLR 是独立的预后因素（p=0.011）。
即使在 pre-NLR 较高的 CRC 患者中，post-NLR 的降低与更好的 OS 和 DFS 相关。
