肥胖症患者减肥手术对血流介导的血管扩张和颈动脉内膜中层厚度的影响：1 年随访研究。
Effect of bariatric surgery on flow-mediated dilation and carotid intima-media thickness in patients with morbid obesity: 1-year follow-up study.
机构信息
Departments of Cardiology, İstanbul Faculty of Medicine, İstanbul University; İstanbul-Turkey.
Department of Internal Medicine, İstanbul Faculty of Medicine, İstanbul University; İstanbul-Turkey.
出版信息
Anatol J Cardiol. 2020 Mar;23(4):218-222. doi: 10.14744/AnatolJCardiol.2019.85249.
OBJECTIVE
Obesity is associated with increased cardiovascular (CV) mortality and morbidity. Bariatric surgery (BS) is currently an established therapeutic approach for severely obese patients. Carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilation (FMD) provide important prognostic information beyond traditional CV risk factors. This study aimed to examine the effect of bariatric surgery-induced weight loss on CIMT and brachial artery FMD in morbidly obese patients.
METHODS
A total of 23 morbidly obese patients (40.4±5.6 years, 13 females) were examined before and after BS for 1 year with 3-month periods. CIMT, FMD, body composition, and metabolic parameters were determined.
RESULTS
All the patients exhibited significant weight loss following BS (p<0.001). Carotid intima-media thickness reduction was not significant from baseline to 6 months (p=0.069), but at 9 months (p=0.004), it became significant. Similarly, the difference between the preoperative and 6-month FMD assessments was not significant (p=0.057), but at 9 months (p<0.001), it became significant.
CONCLUSION
Our study reveals that weight loss following BS causes improvements in CV risk factors, which is evident after 9 months of surgery.
目的
肥胖与心血管（CV）死亡率和发病率的增加有关。减重手术（BS）目前是治疗严重肥胖患者的一种既定方法。颈动脉内膜中层厚度（CIMT）和肱动脉血流介导的扩张（FMD）提供了超越传统心血管危险因素的重要预后信息。本研究旨在研究减重手术引起的体重减轻对病态肥胖患者的 CIMT 和肱动脉 FMD 的影响。
方法
共对 23 名病态肥胖患者（40.4±5.6 岁，13 名女性）进行了检查，在 BS 后 1 年内每 3 个月进行一次检查，共 3 次。测定 CIMT、FMD、身体成分和代谢参数。
结果
所有患者在 BS 后均表现出明显的体重减轻（p<0.001）。从基线到 6 个月时，颈动脉内膜中层厚度的减少不显著（p=0.069），但在 9 个月时（p=0.004），则变得显著。同样，术前和 6 个月时的 FMD 评估之间的差异不显著（p=0.057），但在 9 个月时（p<0.001），则变得显著。
结论
我们的研究表明，BS 后体重减轻会导致心血管危险因素的改善，这在手术后 9 个月时就很明显。
Zotero 插件