Hajsadeghi Shokoufeh, Athar Rahmatullah, Iranpour Aida, Yahyavi Ashkan, Mohebi Nafiseh, Rahimi Amir Hossein
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Hazrat-E Fatemeh Hospital Iran University of Medical Sciences, Tehran, Iran.
Obes Surg. 2025 Apr;35(4):1538-1542. doi: 10.1007/s11695-024-07661-z. Epub 2025 Feb 14.
Cardiovascular disease (CVD) is the main cause of death in patients with obesity. Bariatric surgery has been shown to promote substantial reduction in carotid intima-media thickness (C-IMT).
To comprehensively determine the influence of metabolic and bariatric surgery (MBS) on cardiovascular health in women.
A total of 24 female patients with a body mass index (BMI) > 35 kg/m underwent sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), or one anastomosis gastric bypass (OAGB), a prospective cohort study in women. C-IMT were evaluated at baseline and 24 months post-MBS.
The results showed a significant reduction in BMI, weight, and C-IMT on the right side 24 months post-MBS (p < 0.001 for BMI and weight and p = 0.004 for C-IMT). There were also significant differences in fasting blood sugar (FBS), triglycerides (TG), total cholesterol, and low-density lipoprotein (LDL) levels. However, high-density lipoprotein (HDL) levels did not show a significant change.
The study underscores the potential of MBS in mitigating cardiovascular risk among women with obesity. However, further research is needed to fully understand the impact of MBS on various parameters. The findings highlight the importance of personalized and gender-specific approaches in the management of obesity and related disease.
心血管疾病（CVD）是肥胖患者的主要死因。减肥手术已被证明可显著降低颈动脉内膜中层厚度（C-IMT）。
全面确定代谢与减肥手术（MBS）对女性心血管健康的影响。
对24名体重指数（BMI）>35 kg/m²的女性患者进行了袖状胃切除术（SG）、Roux-en-Y胃旁路术（RYGB）或单吻合口胃旁路术（OAGB），这是一项针对女性的前瞻性队列研究。在基线和MBS术后24个月评估C-IMT。
结果显示，MBS术后24个月，BMI、体重和右侧C-IMT显著降低（BMI和体重p<0.001，C-IMT p=0.004）。空腹血糖（FBS）、甘油三酯（TG）、总胆固醇和低密度脂蛋白（LDL）水平也存在显著差异。然而，高密度脂蛋白（HDL）水平没有显著变化。
该研究强调了MBS在降低肥胖女性心血管风险方面的潜力。然而，需要进一步研究以充分了解MBS对各种参数的影响。研究结果突出了在肥胖及相关疾病管理中采用个性化和针对性别的方法的重要性。
