Research Center of Biochemistry and Advanced Molecular Biology, Department of Experimental and Clinical Medicine, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
Interdepartmental Center of Services (CIS), Department of Experimental and Clinical Medicine, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
Int J Mol Sci. 2020 Mar 30;21(7):2378. doi: 10.3390/ijms21072378.
The T cells are key players of the response to checkpoint blockade immunotherapy (CBI) and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but elusive component of precision immunotherapy. The entire assembly of T-cell receptor (TCR) sequences accounts for antigen specificity and strength of the T-cell immune response. The TCR repertoire hence represents a "footprint" of the conditions faced by T cells that dynamically evolves according to the challenges that arise for the immune system, such as tumor neo-antigenic load. Hence, TCR repertoire analysis is becoming increasingly important to comprehensively understand the nature of a successful antitumor T-cell response, and to improve the success and safety of current CBI.
T 细胞是对检查点阻断免疫疗法（CBI）反应的关键参与者，监测抗肿瘤 T 细胞反应的强度和特异性仍然是精准免疫疗法的一个关键但难以捉摸的组成部分。T 细胞受体（TCR）序列的整体组装决定了 T 细胞的抗原特异性和免疫反应的强度。因此，TCR 库代表了 T 细胞所面临的条件的“足迹”，根据免疫系统面临的挑战（如肿瘤新抗原负荷），它会动态演变。因此，TCR 库分析对于全面了解抗肿瘤 T 细胞反应的性质以及提高当前 CBI 的成功率和安全性变得越来越重要。
