Han Zhiyong, Wang Dan, He Xiaoyan, Xia Qiang
Department of Immunology and Pathogen Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai Guangdong 519041, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Dec 28;49(12):1983-1990. doi: 10.11817/j.issn.1672-7347.2024.240172.
Hepatitis B is a global public health concern. Inducing hepatitis B surface antibody (HBsAb) through vaccination is a crucial preventive strategy. However, individuals show varying immune responses to the hepatitis B vaccine. Based on HBsAb levels, individuals can be categorized as high responders, low responders, or non-responders. T cells and their subsets play critical roles in modulating this response, and the composition of the T cell receptor (TCR) repertoire also influences immune responsiveness. Investigating the characteristics of T cells, their subsets, and TCR repertoires in individuals with differential responses post-vaccination may provide theoretical guidance for optimizing vaccine design and immunization strategies.
乙型肝炎是一个全球公共卫生问题。通过接种疫苗诱导产生乙型肝炎表面抗体（HBsAb）是一项关键的预防策略。然而，个体对乙型肝炎疫苗的免疫反应各不相同。根据HBsAb水平，个体可分为高反应者、低反应者或无反应者。T细胞及其亚群在调节这种反应中起关键作用，T细胞受体（TCR）库的组成也会影响免疫反应性。研究接种疫苗后不同反应个体的T细胞、其亚群和TCR库的特征，可能为优化疫苗设计和免疫策略提供理论指导。
