乙肝疫苗接种后不同免疫反应个体的T细胞特征
T cell characteristics in individuals with different immune responses after hepatitis B vaccination.
作者信息
Han Zhiyong, Wang Dan, He Xiaoyan, Xia Qiang
机构信息
Department of Immunology and Pathogen Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai Guangdong 519041, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Dec 28;49(12):1983-1990. doi: 10.11817/j.issn.1672-7347.2024.240172.
Abstract
Hepatitis B is a global public health concern. Inducing hepatitis B surface antibody (HBsAb) through vaccination is a crucial preventive strategy. However, individuals show varying immune responses to the hepatitis B vaccine. Based on HBsAb levels, individuals can be categorized as high responders, low responders, or non-responders. T cells and their subsets play critical roles in modulating this response, and the composition of the T cell receptor (TCR) repertoire also influences immune responsiveness. Investigating the characteristics of T cells, their subsets, and TCR repertoires in individuals with differential responses post-vaccination may provide theoretical guidance for optimizing vaccine design and immunization strategies.
摘要
乙型肝炎是一个全球公共卫生问题。通过接种疫苗诱导产生乙型肝炎表面抗体（HBsAb）是一项关键的预防策略。然而，个体对乙型肝炎疫苗的免疫反应各不相同。根据HBsAb水平，个体可分为高反应者、低反应者或无反应者。T细胞及其亚群在调节这种反应中起关键作用，T细胞受体（TCR）库的组成也会影响免疫反应性。研究接种疫苗后不同反应个体的T细胞、其亚群和TCR库的特征，可能为优化疫苗设计和免疫策略提供理论指导。
相似文献
1
T cell characteristics in individuals with different immune responses after hepatitis B vaccination.乙肝疫苗接种后不同免疫反应个体的T细胞特征
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Dec 28;49(12):1983-1990. doi: 10.11817/j.issn.1672-7347.2024.240172.
2
Next-generation sequencing analysis of the human T-cell and B-cell receptor repertoire diversity before and after hepatitis B vaccination.乙肝疫苗接种前后人类 T 细胞和 B 细胞受体库多样性的下一代测序分析。
Hum Vaccin Immunother. 2019;15(11):2738-2753. doi: 10.1080/21645515.2019.1600987. Epub 2019 Jul 25.
3
Hepatitis B vaccine responders show higher frequencies of CD8 effector memory and central memory T cells compared to non-responders.乙肝疫苗应答者体内的 CD8 效应记忆 T 细胞和中央记忆 T 细胞频率高于无应答者。
Scand J Immunol. 2024 Nov;100(5):e13402. doi: 10.1111/sji.13402. Epub 2024 Aug 27.
4
Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS-21 induce strong humoral and cellular immune responses against hepatitis B surface antigen which persist for at least 4 years after vaccination.含有单磷酰脂质A和QS-21的疫苗佐剂系统可诱导针对乙肝表面抗原的强烈体液免疫和细胞免疫反应，且在接种疫苗后至少持续4年。
Vaccine. 2015 Feb 18;33(8):1084-91. doi: 10.1016/j.vaccine.2014.10.078. Epub 2014 Nov 7.
5
Profiling T cell receptor β-chain in responders after immunization with recombinant hepatitis B vaccine.分析接种重组乙型肝炎疫苗后应答者的 T 细胞受体 β 链。
J Gene Med. 2021 Sep;23(9):e3367. doi: 10.1002/jgm.3367. Epub 2021 Jun 17.
6
Induction of a robust T- and B-cell immune response in non- and low-responders to conventional vaccination against hepatitis B by using a third generation PreS/S vaccine.使用第三代前S/S疫苗在对传统乙肝疫苗无反应和低反应者中诱导强大的T细胞和B细胞免疫反应。
Vaccine. 2014 Sep 3;32(39):5077-82. doi: 10.1016/j.vaccine.2014.06.076. Epub 2014 Jun 24.
7
Hepatitis B Virus Vaccination in HIV: Immunogenicity and Persistence of Seroprotection up to 7 Years Following a Primary Immunization Course.人类免疫缺陷病毒感染者的乙型肝炎病毒疫苗接种：初次免疫疗程后长达7年的免疫原性及血清保护持久性
AIDS Res Hum Retroviruses. 2018 Nov;34(11):922-928. doi: 10.1089/AID.2017.0070. Epub 2018 Aug 16.
8
HIV viraemia during hepatitis B vaccination shortens the duration of protective antibody levels.乙肝疫苗接种期间的HIV病毒血症会缩短保护性抗体水平的持续时间。
HIV Med. 2015 Mar;16(3):161-7. doi: 10.1111/hiv.12189. Epub 2015 Jan 14.
9
Antibody titration and immune response of Iranian beta-thalassemic patients to hepatitis B virus vaccine (booster effect).伊朗β地中海贫血患者对乙肝疫苗的抗体滴定及免疫反应（加强效应）
Pediatr Hematol Oncol. 2009 Jun;26(4):195-201. doi: 10.1080/08880010902895900.
10
Immunization with a DNA vaccine candidate in chronic hepatitis C patients is safe, well tolerated and does not impair immune response induction after anti-hepatitis B vaccination.在慢性丙型肝炎患者中使用 DNA 疫苗候选物进行免疫接种是安全的，具有良好的耐受性，并且不会损害抗乙型肝炎疫苗接种后的免疫应答诱导。
J Gene Med. 2010 Jan;12(1):107-16. doi: 10.1002/jgm.1407.
本文引用的文献
1
Identification of Treg-related prognostic molecular subtypes and individualized characteristics in clear cell renal cell carcinoma through single-cell transcriptomes and bulk RNA sequencing.通过单细胞转录组和批量RNA测序鉴定透明细胞肾细胞癌中与调节性T细胞相关的预后分子亚型及个体特征
Int Immunopharmacol. 2024 Mar 30;130:111746. doi: 10.1016/j.intimp.2024.111746. Epub 2024 Mar 4.
2
T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance.滤泡辅助性 T 细胞 17（Tfh17）细胞在维持免疫记忆方面更具优势。
Elife. 2023 Jan 19;12:e82217. doi: 10.7554/eLife.82217.
3
HBV immune tolerance of HBs-transgenic mice observed through parabiosis with WT mice.通过与野生型小鼠联体观察 HBs 转基因小鼠的 HBV 免疫耐受。
Front Immunol. 2022 Sep 20;13:993246. doi: 10.3389/fimmu.2022.993246. eCollection 2022.
4
Complementary Presence of HBV Humoral and T-cell Response Provides Protective Immunity after Neonatal Immunization.乙肝病毒体液免疫和T细胞反应的互补存在为新生儿免疫接种后提供保护性免疫。
J Clin Transl Hepatol. 2022 Aug 28;10(4):660-668. doi: 10.14218/JCTH.2021.00272. Epub 2022 Jan 4.
5
Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity.感染和自身免疫疾病的小鼠模型中 B 细胞和 T 细胞的单细胞免疫受体库测序。
Genes Immun. 2022 Sep;23(6):183-195. doi: 10.1038/s41435-022-00180-w. Epub 2022 Aug 26.
6
Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.全球、区域和国家乙型肝炎负担，1990-2019 年：基于 2019 年全球疾病负担研究的系统分析。
Lancet Gastroenterol Hepatol. 2022 Sep;7(9):796-829. doi: 10.1016/S2468-1253(22)00124-8. Epub 2022 Jun 21.
7
Characterization of the TCR β Chain Repertoire in Peripheral Blood from Hepatitis B Vaccine Responders and Non-Responders.乙肝疫苗应答者和无应答者外周血中TCRβ链库的特征分析
J Inflamm Res. 2022 Feb 14;15:939-951. doi: 10.2147/JIR.S347702. eCollection 2022.
8
Single-cell transcriptomics analysis reveals intratumoral heterogeneity and identifies a gene signature associated with prognosis of hepatocellular carcinoma.单细胞转录组学分析揭示了肿瘤内异质性，并确定了一个与肝细胞癌预后相关的基因特征。
Biosci Rep. 2022 Feb 25;42(2). doi: 10.1042/BSR20212560.
9
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma.与黑色素瘤患者免疫检查点阻断毒性相关的 T 细胞特征。
Nat Med. 2022 Feb;28(2):353-362. doi: 10.1038/s41591-021-01623-z. Epub 2022 Jan 13.
10
Undetectable Anti-HBs Antibodies: Need of a Booster Dose for HIV-1-Infected Individuals.无法检测到的抗-HBs抗体：HIV-1感染个体需要加强剂量
Vaccines (Basel). 2021 Dec 15;9(12):1484. doi: 10.3390/vaccines9121484.
Zotero 插件