Molecular Sciences Research Hub, Department of Chemistry, White City Campus, Imperial College London, London, W12 0BZ, UK.
School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Chem Commun (Camb). 2020 Apr 14;56(29):4037-4046. doi: 10.1039/d0cc00196a. Epub 2020 Apr 1.
Over the last decade, much work has been dedicated to improving the performance of gadolinium-based magnetic resonance imaging (MRI) contrast agents by tethering them to biocompatible gold nanoparticles. The enhancement in performance (measured in terms of 'relaxivity') stems from the restriction in motion experienced by the gadolinium chelates on being attached to the gold nanoparticle surface. More recently, the unique properties of gold nanoparticles have been exploited to create very promising tools for multimodal imaging and MRI-guided therapies. This review addresses the progress made in the design of gadolinium-functionalised gold nanoparticles for use in MRI, multimodal imaging and theranostics. It also seeks to connect the chemical properties of these assemblies with potential application in the clinic.
在过去的十年中，人们致力于通过将其连接到生物相容性的金纳米粒子上来提高基于钆的磁共振成像（MRI）造影剂的性能。通过将其连接到金纳米粒子表面，性能（以“弛豫率”来衡量）的提高源于对被附着的钆螯合物的运动的限制。最近，金纳米粒子的独特性质被用于开发非常有前途的多模式成像和 MRI 引导治疗的工具。本综述介绍了用于 MRI、多模态成像和治疗学的功能化金纳米粒子的设计方面的进展。它还试图将这些组装体的化学性质与在临床中的潜在应用联系起来。
