Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London W12 0BZ, United Kingdom.
Nanotheranostics. 2021 Jan 15;5(2):155-165. doi: 10.7150/ntno.56432. eCollection 2021.
Gold nanorods (GNRs) show great promise as photothermal therapy agents due to their remarkable ability to convert light into heat. In most cases, gold nanorods are synthesised via a seed-mediated method assisted by surfactants. However, the toxicity of these surfactants, principally cetrimonium ions, has prevented GNRs from being used more widely . To address this issue, various detoxification and functionalisation approaches have been proposed in recent years to replace or cover surfactant coatings on the gold surface. In this short review, the advantages and limitations of each approach are examined in the context of the recent progress made towards the design of GNRs suitable for use in the body.
金纳米棒（GNRs）由于其将光转化为热的非凡能力，有望成为光热治疗剂。在大多数情况下，金纳米棒是通过种子介导的方法在表面活性剂的辅助下合成的。然而，这些表面活性剂（主要是十六烷基三甲基溴化铵）的毒性限制了 GNRs 的更广泛应用。为了解决这个问题，近年来提出了各种解毒和功能化方法，以取代或覆盖金表面的表面活性剂涂层。在这篇简短的综述中，根据最近在设计适合体内使用的 GNRs 方面取得的进展，研究了每种方法的优缺点。
