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Acetaminophen-induced hepatotoxicity: different mechanisms of acetaminophen-induced ferroptosis and mitochondrial damage.

作者信息

Yamada Naoya, Komada Takanori, Ohno Nobuhiko, Takahashi Masafumi

机构信息

Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University, Tochigi, Japan.

出版信息

Arch Toxicol. 2020 Jun;94(6):2255-2257. doi: 10.1007/s00204-020-02722-5. Epub 2020 Mar 31.

DOI:10.1007/s00204-020-02722-5
PMID:32236649
Abstract
摘要

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本文引用的文献

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Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.自由基氧化 n-6 多不饱和脂肪酸驱动的铁死亡介导对乙酰氨基酚诱导的急性肝衰竭。
Cell Death Dis. 2020 Feb 24;11(2):144. doi: 10.1038/s41419-020-2334-2.
2
The chemical basis of ferroptosis.铁死亡的化学基础。
Nat Chem Biol. 2019 Dec;15(12):1137-1147. doi: 10.1038/s41589-019-0408-1. Epub 2019 Nov 18.
3
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.辅酶 Q 氧化还原酶 FSP1 与 GPX4 平行作用以抑制铁死亡。
铁死亡的新兴机制及其疾病影响:天然产物的潜在应用
Front Cell Dev Biol. 2022 Jan 18;9:774957. doi: 10.3389/fcell.2021.774957. eCollection 2021.
Nature. 2019 Nov;575(7784):688-692. doi: 10.1038/s41586-019-1705-2. Epub 2019 Oct 21.
4
FSP1 is a glutathione-independent ferroptosis suppressor.FSP1 是一种谷胱甘肽不依赖的铁死亡抑制因子。
Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21.
5
Role of Mitochondria in Ferroptosis.线粒体在铁死亡中的作用。
Mol Cell. 2019 Jan 17;73(2):354-363.e3. doi: 10.1016/j.molcel.2018.10.042. Epub 2018 Dec 20.
6
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?未解之谜:脂质过氧化如何引发铁死亡?
PLoS Biol. 2018 May 24;16(5):e2006203. doi: 10.1371/journal.pbio.2006203. eCollection 2018 May.
7
Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis.铁抑素抑制铁死亡的亚细胞定位和作用机制的确定。
ACS Chem Biol. 2018 Apr 20;13(4):1013-1020. doi: 10.1021/acschembio.8b00199. Epub 2018 Mar 13.
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Simple kinetic model of mitochondrial swelling in cardiac cells.心肌细胞中线粒体肿胀的简单动力学模型。
J Cell Physiol. 2018 Jul;233(7):5310-5321. doi: 10.1002/jcp.26335. Epub 2018 Jan 23.
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