School of Chemical Sciences, Central University of Gujarat, Gandhinagar, 382030, India.
Anal Bioanal Chem. 2020 May;412(13):3177-3186. doi: 10.1007/s00216-020-02573-0. Epub 2020 Mar 31.
A facile green method for the mechanochemical synthesis of Schiff base phenylhydrazono-N-methylene fluorescein (PHMF) with 95% yields has been established. The synthesized receptor assists in the naked-eye detection of CN ions in organic and aqueous media, and F ions in acetonitrile over a series of anions with a color transfer from colorless to pink. A redshift of 160 nm of PHMF-CN complex in the absorbance spectrum and a turn-on response in the fluorescence spectrum were observed, respectively, at λmax 345 to 515 and 519 nm. A strong interaction of PHMF with CN and F ions forming a 1:3 binding stoichiometry has been noted in this study. In an aqueous medium for CN ion, the lower limit of detection (LOD) is defined as 9.204 nM, which is quite better in terms of sensitivity. In addition, PHMF's paper-strip sensor for rapid real-time CN ion sensing was found to be sufficiently sensitive to successfully detect CN ion in water and a solid state, resulting in a portable device for detecting cyanide ions. In acetonitrile, the receptor's ability to detect CN ion in cigarette smoke residue was also satisfactorily achieved. Graphical Abstract.
已建立了一种简便的机械化学合成席夫碱苯腙-N-亚甲基荧光素（PHMF）的方法，产率为 95%。所合成的受体能够在有机溶剂和水介质中通过颜色从无色变为粉红色来协助对 CN 离子进行肉眼检测，以及在乙腈中对 F 离子进行检测，其中对一系列阴离子进行了检测。在吸收光谱中观察到 PHMF-CN 配合物的 160nm 红移，在荧光光谱中观察到开启响应，最大吸收波长分别为 345nm 至 515nm 和 519nm。本研究表明，PHMF 与 CN 和 F 离子之间存在强烈的相互作用，形成 1:3 的结合计量关系。在 CN 离子的水介质中，检测限（LOD）定义为 9.204nM，灵敏度相当高。此外，PHMF 的纸质传感器可用于快速实时检测 CN 离子，已成功检测到水中和固态的 CN 离子，从而可用于检测氰化物离子的便携设备。在乙腈中，该受体也能够令人满意地检测到香烟烟尘中的 CN 离子。
