通过 AT 钩适应子在特定 DNA 位点组装三元金属肽复合物。
Assembly of a Ternary Metallopeptide Complex at Specific DNA Sites Mediated by an AT-Hook Adaptor.
机构信息
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and, Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
出版信息
Chemistry. 2020 Jul 22;26(41):8875-8878. doi: 10.1002/chem.202001277. Epub 2020 Jul 8.
The nickel(II)-mediated self-assembly of a multimeric DNA binder is described. The binder is composed of two metal-chelating peptides derived from a bZIP transcription factor (brHis ) and one short AT-hook domain equipped with two bipyridine ligands (HkBpy ). These peptides reversibly assemble in the presence of Ni ions at selected DNA sequences of 13 base pairs.
描述了一种由多聚体 DNA 结合物介导的镍（II）自组装。该结合物由两个来源于 bZIP 转录因子的金属螯合肽（brHis）和一个带有两个双吡啶配体（HkBpy）的短 AT 钩结构域组成。这些肽在 Ni 离子存在下可以在 13 个碱基对的特定 DNA 序列处可逆组装。
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