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手性选择性 DNA 结合螺旋体的自组装由病毒 β-环三聚肽基序指导。

Stereoselective Self-Assembly of DNA Binding Helicates Directed by the Viral β-Annulus Trimeric Peptide Motif.

机构信息

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Inorgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

出版信息

Bioconjug Chem. 2021 Aug 18;32(8):1564-1569. doi: 10.1021/acs.bioconjchem.1c00312. Epub 2021 Jul 28.

DOI:10.1021/acs.bioconjchem.1c00312
PMID:34320309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8485332/
Abstract

Combining coordination chemistry and peptide engineering offers extraordinary opportunities for developing novel molecular (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2'-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions.

摘要

结合配位化学和肽工程为开发新型分子（超分子）结构提供了非凡的机会。在这里，我们证明β-环糊精结构能够指导含有 2,2'-联吡啶配体的设计肽的立体选择性组装成平行的三股手性肽螺旋，并且这些螺旋选择性地以高亲和力结合三链 DNA 结。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/5c732f184fa5/bc1c00312_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/42ceca012a30/bc1c00312_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/334cc614b709/bc1c00312_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/43da460580c0/bc1c00312_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/276a17f75d4a/bc1c00312_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/5c732f184fa5/bc1c00312_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/42ceca012a30/bc1c00312_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/334cc614b709/bc1c00312_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/43da460580c0/bc1c00312_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/276a17f75d4a/bc1c00312_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b703/8485332/5c732f184fa5/bc1c00312_0004.jpg

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Angew Chem Int Ed Engl. 2021 Apr 12;60(16):8859-8866. doi: 10.1002/anie.202013039. Epub 2021 Jan 28.
3
Dynamic Helicates Self-Assembly from Homo- and Heterotopic Dynamic Covalent Ligand Strands.
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4
Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks.有机金属柱芳烃能与 DNA 四链体 Holliday 连接点和分叉结合。
J Am Chem Soc. 2023 Jun 28;145(25):13570-13580. doi: 10.1021/jacs.3c00118. Epub 2023 Jun 15.
动态同金属和杂金属螯合物自组装来自同和异位动态共价配体链。
Chemistry. 2020 Dec 1;26(67):15664-15671. doi: 10.1002/chem.202003496. Epub 2020 Oct 19.
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Dinuclear Triple-Stranded Helicates Composed of Tetradentate Ligands with Aluminum(III) Chromophores: Optical Resolution and Multi-color Circularly Polarized Luminescence Properties.由含铝（III）发色团的四齿配体组成的双核三链螺旋配合物：光学拆分及多色圆偏振发光性质
Angew Chem Int Ed Engl. 2021 Feb 1;60(5):2614-2618. doi: 10.1002/anie.202011450. Epub 2020 Dec 1.
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