Yang Guang, He Hao-Qiang, Chen Guang, Wang Jie
Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China Beijing University of Chinese Medicine Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2020 Jan;45(1):29-36. doi: 10.19540/j.cnki.cjcmm.20190505.502.
Ischemic heart disease has became the world's most common deadly disease, and coronary heart disease(CHD) is the most common type of ischemic heart disease. The pathological mechanism of CHD has not been fully elucidated. In recent years, scientific studies have found that gut micro-biota are closely related to the occurrence and development of CHD, and CHD could be intervened by regulating gut micro-biota because of the correlation between CHD and intermediate metabolite of gut micro-biota. Current intervention strategies mainly include probiotics supplementation, reduction of TMAO and increase of SCFAs, which can achieve the effect of stabilizing plaques, and controlling blood pressure, blood lipids, blood glucose and obesity. Traditional Chinese medicine(TCM) has the multi-component and multi-target effects, which is correlated to its role in the prevention and treatment of CHD. This paper summarizes the domestic and foreign researches on the effect of TCM in attenuating CHD and its main risk factors by regulating gut micro-biota. The article aims to explore the correlation between gut micro-biota and CHD, and propose three main intervention strategies. Furthermore, the research progress of TCM on CHD, hypertension, dyslipidemia, hyperglycemia and obesity is reviewed by the categories of Chinese medicine monomer and compound, in the hope to provide more theoretical basis for TCM therapy on CHD and guidance for further studies in this field.
缺血性心脏病已成为全球最常见的致命疾病，而冠心病是缺血性心脏病最常见的类型。冠心病的病理机制尚未完全阐明。近年来，科学研究发现肠道微生物群与冠心病的发生发展密切相关，且由于冠心病与肠道微生物群中间代谢产物的相关性，可通过调节肠道微生物群对冠心病进行干预。目前的干预策略主要包括补充益生菌、降低氧化三甲胺（TMAO）以及增加短链脂肪酸（SCFAs），这些措施可起到稳定斑块、控制血压、血脂、血糖及肥胖的作用。中药具有多成分、多靶点效应，这与其在冠心病防治中的作用相关。本文综述了国内外关于中药通过调节肠道微生物群减轻冠心病及其主要危险因素的研究。文章旨在探讨肠道微生物群与冠心病之间的相关性，并提出三种主要干预策略。此外，按中药单体和复方类别对中药治疗冠心病、高血压、血脂异常、高血糖及肥胖症的研究进展进行了综述，以期为中药治疗冠心病提供更多理论依据，并为该领域的进一步研究提供指导。
