Sang Ting-Ting, Guo Cheng-Jie, Guo Dan-Dan, Wang Xing-Ya
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 311400, China.
Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(16):3235-3242. doi: 10.19540/j.cnki.cjcmm.20180423.003.
Traditional Chinese medicine(TCM) has been increasingly used in the prevention and treatment of obesity and obesity-related diseases. However, its mechanism of action is not yet clear. In recent years, with the development of high-throughput sequencing technology, scientific researches have found that the disorder of gut microbiota is associated with obesity and other diseases. Furthermore, it has been found that TCM can improve the structure of gut microbiota by increasing probiotics and reducing pathogens, which play an importent role in preventing the development and progression of obesity and other diseases. This article first explores the possible association between intestinal microbiota and obesity. Then, it reviews the traditional Chinese medicine and its role in regulating intestinal microbiota for the prevention and treatment of diseases, including obesity and inflammation, insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, inflammatory bowel disease and other diseases, in theexpectation of new strategies and research direction for treating obesity and relevant diseases, and providing important guidance for further studies in this field in the future.
中医已越来越多地用于肥胖症及肥胖相关疾病的防治。然而,其作用机制尚不清楚。近年来,随着高通量测序技术的发展,科学研究发现肠道微生物群紊乱与肥胖症及其他疾病有关。此外,还发现中医可通过增加益生菌和减少病原体来改善肠道微生物群结构,这对预防肥胖症及其他疾病的发生和发展起着重要作用。本文首先探讨肠道微生物群与肥胖症之间可能存在的关联。然后,综述中医及其在调节肠道微生物群以防治疾病(包括肥胖症、炎症、胰岛素抵抗、2型糖尿病、非酒精性脂肪性肝病、炎症性肠病等疾病)方面的作用,以期为治疗肥胖症及相关疾病提供新策略和研究方向,并为该领域未来的进一步研究提供重要指导。