7938 Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
7985 Division of Dermatology, Women's College Hospital and University of Toronto, and Women's College Research Institute, ON, Canada.
J Cutan Med Surg. 2020 May/Jun;24(3):267-272. doi: 10.1177/1203475420911896. Epub 2020 Apr 2.
Atopic dermatitis (AD) is a chronic skin disease characterized by barrier dysfunction and immune dysregulation that affects approximately 20% of children and 2-5% of adults worldwide. Traditionally, AD has been considered a disease of childhood with many cases resolving before adulthood. However, in recent years, the prevalence of adult AD is increasingly recognized to be substantial, but it is uncertain whether this increase is due to increased childhood-persistent or relapsed AD, or new adult-onset AD. This highlights a need for further investigation into the adult AD population and evaluation of phenotypes in the adult-onset cohort. In this literature review, we examine five studies focused on adult-onset AD phenotype, conducted between 2013 and 2017. The most commonly reported body regions affected in adult-onset AD were the hands, eyelids, neck, and flexural surfaces of the upper limbs. These vary from childhood-onset AD findings, which are less specific to body regions other than flexural areas. These findings have implications for diagnostic accuracy and treatment of AD, including considerations for therapeutic choices and inclusion and exclusion criteria in clinical trials.
特应性皮炎（AD）是一种慢性皮肤病，其特征为屏障功能障碍和免疫失调，影响着全球约 20%的儿童和 2-5%的成年人。传统上，AD 被认为是一种儿童疾病，许多病例在成年前就已痊愈。然而，近年来，成人 AD 的患病率越来越被认为是相当高的，但尚不确定这种增加是由于儿童期持续性 AD 或复发 AD 的增加，还是新的成人发病 AD。这凸显了需要进一步研究成人 AD 人群，并评估成人发病队列的表型。在这篇文献综述中，我们研究了 2013 年至 2017 年期间进行的五项专注于成人发病 AD 表型的研究。在成人发病 AD 中最常报告受影响的身体部位是手部、眼睑、颈部和上肢的屈侧表面。这些与儿童发病 AD 的发现不同，后者对除屈侧部位以外的身体部位的特异性较低。这些发现对 AD 的诊断准确性和治疗具有影响，包括对治疗选择以及临床试验中的纳入和排除标准的考虑。
