从内生真菌 Aplosporella javeedii 中分离得到的抗真菌聚酮衍生物。
Antifungal polyketide derivatives from the endophytic fungus Aplosporella javeedii.
机构信息
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
出版信息
Bioorg Med Chem. 2020 May 15;28(10):115456. doi: 10.1016/j.bmc.2020.115456. Epub 2020 Mar 25.
Six new polyketides aplojaveediins A-F (1-6) were isolated from the endophytic fungus Aplosporella javeedii associated with the host plant Orychophragmus violaceus (Brassicaceae). The structures of the new metabolites were elucidated by analysis of their NMR and MS data. Compound 1 exhibited antifungal activity against the hyphae form of Candida albicans strain ATCC 24433 in the agar plate diffusion assay and the microbroth dilution assay. The kinetic of killing of C. albicans cells for compound 1 was considerably faster than that of the positive control hygromycin B. Compounds 1 and 6 also exhibited moderate antibacterial activities against sensitive (ATCC 29213) and drug-resistant (ATCC 700699) strains of Staphylococcus aureus.
从与宿主植物 Orychophragmus violaceus（十字花科）相关的内生真菌 Aplosporella javeedii 中分离得到了六种新的聚酮类化合物 aplojaveediins A-F（1-6）。通过分析它们的 NMR 和 MS 数据，阐明了新代谢物的结构。化合物 1 在琼脂平板扩散试验和微量稀释试验中对白色念珠菌 ATCC 24433 菌丝形式表现出抗真菌活性。化合物 1 杀死念珠菌细胞的动力学明显快于阳性对照 Hygromycin B。化合物 1 和 6 对敏感（ATCC 29213）和耐药（ATCC 700699）金黄色葡萄球菌菌株也表现出中等的抗菌活性。
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