Moreno Leandro Ferreira, Menezes da Silva Nickolas, Weiss Vinicius Almir, de Fátima Costa Flavia, Bittencourt Juliana V, Macedo Luciano Medina, Gomes Renata R, Souza Emanuel M, Vicente Vania Aparecida, Stielow Benjamin, de Hoog Sybren
Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands.
G3 (Bethesda). 2020 Jun 1;10(6):1817-1821. doi: 10.1534/g3.119.400831.
The black yeast-like fungus is known from strains that cause severe and eventually fatal disseminated infections in immunocompromised patients. Given the dramatic outcome of this clinical case, it is essential to understand the virulence potential of this species. The fungus is a member of the family , at some phylogenetic distance from the where most infectious fungi in the order are located. Main ecological preferences among include colonization of exposed inert surfaces. Currently, black yeasts genomes that are available in public databases cover members of the families and In the present report, we sequenced the genome of the first member and only clinical representative of the family .
这种黑色酵母样真菌可从一些菌株中分离得到，这些菌株会在免疫功能低下的患者中引起严重且最终致命的播散性感染。鉴于该临床病例的严重后果，了解该菌种的毒力潜力至关重要。该真菌是[具体科名]家族的成员，与[该目大多数感染性真菌所在的科]在系统发育上有一定距离。[该目真菌]的主要生态偏好包括在暴露的惰性表面定殖。目前，公共数据库中可获取的黑色酵母基因组涵盖了[其他科名]和[另一科名]家族的成员。在本报告中，我们对[该科名]家族的首个成员且唯一的临床代表菌株进行了全基因组测序。
