延缓衰老可促进肝脏再生。
Blunting senescence boosts liver regeneration.
机构信息
MRC London Institute of Medical Sciences, London W12 0NN, United Kingdom.
Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.
出版信息
Genes Dev. 2020 Apr 1;34(7-8):463-464. doi: 10.1101/gad.337394.120.
The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of , Ritschka and colleagues (pp. 489-494). compare liver regeneration upon partial hepatectomy in young and adult mice. Partial hepatectomy causes a transient increase in p21 in a subpopulation of hepatocytes that persists in adult mice. Remarkably, treatment with the BCL-2 family inhibitor ABT-737 blunts p21 expression, enhancing liver regeneration.
哺乳动物的肝脏具有独特的再生能力。然而，这种再生潜力会随着年龄的增长而下降，其具体机制尚不清楚。在本期杂志的 中，Ritschka 及其同事（第 489-494 页）比较了年轻和成年小鼠肝部分切除后的肝再生情况。肝部分切除会导致一小部分肝细胞中的 p21 短暂增加，而这种情况在成年小鼠中持续存在。值得注意的是，用 BCL-2 家族抑制剂 ABT-737 处理会抑制 p21 的表达，从而增强肝再生。
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