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Prevention of bone disease and early detection of impending fractures in multiple myeloma patients can reduce morbidity and mortality: the necessity of interdisciplinary state-of-the-art treatment.预防骨髓瘤患者的骨病并早期发现即将发生的骨折可降低发病率和死亡率：多学科前沿治疗的必要性。
Haematologica. 2020 Apr;105(4):859-861. doi: 10.3324/haematol.2019.245423.
2
[Multiple bone myeloma].多发性骨髓瘤
Rev Prat. 2013 Jan;63(1):101-8.
3
[Multiple myeloma of the bone].[骨多发性骨髓瘤]
Rev Prat. 2002 Jan 1;52(1):63-70.
4
Healthcare resource utilisation associated with skeletal-related events in European patients with multiple myeloma: Results from a prospective, multinational, observational study.欧洲多发性骨髓瘤患者骨骼相关事件的医疗资源利用情况：一项前瞻性、多中心、观察性研究的结果。
Eur J Haematol. 2018 May;100(5):479-487. doi: 10.1111/ejh.13044. Epub 2018 Mar 22.
5
Bisphosphonates in multiple myeloma.双膦酸盐在多发性骨髓瘤中的应用
Cochrane Database Syst Rev. 2001(4):CD003188. doi: 10.1002/14651858.CD003188.
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Bisphosphonates in multiple myeloma.双膦酸盐在多发性骨髓瘤中的应用
Cochrane Database Syst Rev. 2002(3):CD003188. doi: 10.1002/14651858.CD003188.
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Monoclonal gammopathy of undetermined significance, multiple myeloma, and osteoporosis.意义未明的单克隆丙种球蛋白病、多发性骨髓瘤和骨质疏松症。
Joint Bone Spine. 2010 Mar;77(2):120-4. doi: 10.1016/j.jbspin.2009.12.002. Epub 2010 Jan 25.
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Fracture risk with multiple myeloma: a population-based study.多发性骨髓瘤的骨折风险：一项基于人群的研究。
J Bone Miner Res. 2005 Mar;20(3):487-93. doi: 10.1359/JBMR.041131. Epub 2004 Nov 29.
9
[Management of multiple myeloma-related bone disease].[多发性骨髓瘤相关骨病的管理]
Przegl Lek. 2013;70(11):950-7.
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Bisphosphonates for Patients Diagnosed With Multiple Myeloma.双磷酸盐类药物用于多发性骨髓瘤患者。
JAMA. 2018 Oct 9;320(14):1483-1484. doi: 10.1001/jama.2018.13773.

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1
Analysis of skeletal pain, general symptoms and patient-reported outcome measures and their value in detecting symptomatic progression - An interdisciplinary prospective study in patients with multiple myeloma.骨骼疼痛、一般症状及患者报告结局指标分析及其在检测症状进展中的价值——一项针对多发性骨髓瘤患者的跨学科前瞻性研究
J Bone Oncol. 2025 May 8;52:100685. doi: 10.1016/j.jbo.2025.100685. eCollection 2025 Jun.
2
Visual assessment and quantitative analysis of dual-energy CT virtual non-calcium in imaging diagnosis of multiple myeloma.双能CT虚拟去钙成像在多发性骨髓瘤诊断中的视觉评估与定量分析
Skeletal Radiol. 2025 May;54(5):1059-1070. doi: 10.1007/s00256-024-04805-1. Epub 2024 Oct 8.
3
Adherence to the evidence-based recommendations in managing bone health, pain, and mobility of patients with multiple myeloma: a mixed method in the Palestinian healthcare system.在巴勒斯坦医疗体系中，采用混合方法评估多发性骨髓瘤患者的骨健康、疼痛和活动能力管理中遵循基于证据的推荐的情况。
BMC Cancer. 2024 Mar 5;24(1):301. doi: 10.1186/s12885-024-12024-z.
4
The incidence of vertebral compression fractures and spinal instability in newly diagnosed multiple myeloma patients.新诊断的多发性骨髓瘤患者中椎体压缩骨折和脊柱不稳定的发生率。
J Orthop. 2023 Mar 21;38:62-67. doi: 10.1016/j.jor.2023.03.008. eCollection 2023 Apr.
5
[Clinical Application and Limitations of Myeloma Response Assessment and Diagnosis System (MY-RADS)].[骨髓瘤反应评估与诊断系统（MY-RADS）的临床应用及局限性]
J Korean Soc Radiol. 2023 Jan;84(1):51-74. doi: 10.3348/jksr.2022.0154. Epub 2023 Jan 30.
6
Choosing the Right Therapy for Patients with Relapsed/Refractory Multiple Myeloma (RRMM) in Consideration of Patient-, Disease- and Treatment-Related Factors.考虑患者、疾病和治疗相关因素，为复发/难治性多发性骨髓瘤（RRMM）患者选择合适的治疗方法。
Cancers (Basel). 2021 Aug 26;13(17):4320. doi: 10.3390/cancers13174320.

本文引用的文献

1
Fractures and survival in multiple myeloma: results from a population-based study.多发性骨髓瘤的骨折与生存：一项基于人群的研究结果。
Haematologica. 2020 Apr;105(4):1067-1073. doi: 10.3324/haematol.2019.230011. Epub 2019 Dec 2.
2
International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders.国际骨髓瘤工作组关于单克隆浆细胞疾病影像学的共识建议。
Lancet Oncol. 2019 Jun;20(6):e302-e312. doi: 10.1016/S1470-2045(19)30309-2.
3
The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG).经皮椎体成形术和球囊椎体后凸成形术联合骨水泥强化治疗多发性骨髓瘤椎体压缩骨折的作用：国际骨髓瘤工作组（IMWG）的共识声明。
Blood Cancer J. 2019 Feb 26;9(3):27. doi: 10.1038/s41408-019-0187-7.
4
Myeloma bone disease: from biology findings to treatment approaches.多发性骨髓瘤骨病：从生物学发现到治疗方法。
Blood. 2019 Apr 4;133(14):1534-1539. doi: 10.1182/blood-2018-11-852459. Epub 2019 Feb 13.
5
Role of Osteocytes in Myeloma Bone Disease: Anti-sclerostin Antibody as New Therapeutic Strategy.破骨细胞在骨髓瘤骨病中的作用：抗硬骨素抗体作为新的治疗策略。
Front Immunol. 2018 Oct 24;9:2467. doi: 10.3389/fimmu.2018.02467. eCollection 2018.
6
Multidisciplinary Approach for Bone Metastasis: A Review.骨转移的多学科治疗方法：综述
Cancers (Basel). 2018 May 24;10(6):156. doi: 10.3390/cancers10060156.
7
Osteoprotective medication in the era of novel agents: a European perspective on values, risks and future solutions.新型药物时代的骨保护药物：欧洲对价值、风险及未来解决方案的观点
Haematologica. 2018 May;103(5):755-758. doi: 10.3324/haematol.2018.188516.
8
Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study.地舒单抗对比唑来膦酸在初诊多发性骨髓瘤骨病治疗中的应用：一项国际性、双盲、双模拟、随机、对照、3 期研究。
Lancet Oncol. 2018 Mar;19(3):370-381. doi: 10.1016/S1470-2045(18)30072-X. Epub 2018 Feb 9.
9
Pathogenesis of bone disease in multiple myeloma: from bench to bedside.多发性骨髓瘤中骨病的发病机制：从基础到临床。
Blood Cancer J. 2018 Jan 12;8(1):7. doi: 10.1038/s41408-017-0037-4.
10
Bisphosphonates in multiple myeloma: an updated network meta-analysis.双膦酸盐类药物在多发性骨髓瘤中的应用：一项更新的网状Meta分析
Cochrane Database Syst Rev. 2017 Dec 18;12(12):CD003188. doi: 10.1002/14651858.CD003188.pub4.

Prevention of bone disease and early detection of impending fractures in multiple myeloma patients can reduce morbidity and mortality: the necessity of interdisciplinary state-of-the-art treatment.

作者信息

Herget Georg W, Wäsch Ralph, Klein Lukas, Schmal Hagen, Terpos Evangelos, Engelhardt Monika

机构信息

Department of Orthopaedics and Trauma Surgery, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany

Comprehensive Cancer Center Freiburg (CCCF), Medical Center University of Freiburg, Freiburg, Germany.

出版信息

Haematologica. 2020 Apr;105(4):859-861. doi: 10.3324/haematol.2019.245423.

DOI:10.3324/haematol.2019.245423
PMID:32238466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7109744/
Abstract
摘要