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从cDNA序列推导的人红细胞膜阴离子转运蛋白的完整氨基酸序列。

The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence.

作者信息

Tanner M J, Martin P G, High S

机构信息

Department of Biochemistry, School of Medical Sciences, University of Bristol, U.K.

出版信息

Biochem J. 1988 Dec 15;256(3):703-12. doi: 10.1042/bj2560703.

DOI:10.1042/bj2560703
PMID:3223947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1135473/
Abstract
  1. We have isolated cDNA clones corresponding to the red cell membrane anion-transport protein (Band 3). 2. The cDNA clones cover 3475 bases of the mRNA and contain the entire protein-coding region, 150 bases of the 5' untranslated region and part of the 3' non-coding region, but do not extend to the 3' end of the mRNA. 3. The translated protein sequence predicts that the human red cell anion transporter contains 911 amino acids. 4. The availability of the amino acid sequence allows the interpretation of some of the many studies on the chemical and proteolytic modification of the human protein aimed at examining the structure and mechanism of this membrane transport protein.
摘要
  1. 我们已经分离出了与红细胞膜阴离子转运蛋白（带3）相对应的cDNA克隆。2. 这些cDNA克隆覆盖了mRNA的3475个碱基，包含整个蛋白质编码区、5'非翻译区的150个碱基以及3'非编码区的一部分，但并未延伸至mRNA的3'末端。3. 翻译后的蛋白质序列预测人类红细胞阴离子转运蛋白包含911个氨基酸。4. 氨基酸序列的可得性使得对旨在研究这种膜转运蛋白结构和机制的人类蛋白质化学及蛋白水解修饰的众多研究中的一些研究结果得以解读。

相似文献

1
The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence.从cDNA序列推导的人红细胞膜阴离子转运蛋白的完整氨基酸序列。
Biochem J. 1988 Dec 15;256(3):703-12. doi: 10.1042/bj2560703.
2
Primary structure of the rat kidney band 3 anion exchange protein deduced from a cDNA.从cDNA推导的大鼠肾带3阴离子交换蛋白的一级结构
J Biol Chem. 1989 May 15;264(14):8185-92.
3
Amino acid sequence of band-3 protein from rainbow trout erythrocytes derived from cDNA.源自cDNA的虹鳟红细胞带3蛋白的氨基酸序列。
Biochem J. 1992 Jul 1;285 ( Pt 1)(Pt 1):17-23. doi: 10.1042/bj2850017.
4
Co-expressed complementary fragments of the human red cell anion exchanger (band 3, AE1) generate stilbene disulfonate-sensitive anion transport.人红细胞阴离子交换蛋白（带3，AE1）的共表达互补片段产生对二苯乙烯二磺酸盐敏感的阴离子转运。
J Biol Chem. 1995 Apr 21;270(16):9097-105. doi: 10.1074/jbc.270.16.9097.
5
Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1).人类红细胞阴离子交换蛋白（AE1）即带3蛋白的克隆与特性分析
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9089-93. doi: 10.1073/pnas.86.23.9089.
6
Structure of the murine anion exchange protein.
J Cell Biochem. 1985;29(1):1-17. doi: 10.1002/jcb.240290102.
7
Cloning of cDNAs encoding a rabbit renal brush border membrane protein immunologically related to band 3. Sequence similarity with microsomal dipeptidase.编码与带3免疫相关的兔肾刷状缘膜蛋白的cDNA克隆。与微粒体二肽酶的序列相似性。
Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):71-8. doi: 10.1042/bj2800071.
8
Human erythroid band 3 "anion exchanger 1" is expressed in transformed lymphocytes.人类红细胞带3“阴离子交换蛋白1”在转化淋巴细胞中表达。
Cell Mol Biol (Noisy-le-grand). 1996 Nov;42(7):945-52.
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Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line.从小鼠肾脏和一种淋巴样细胞系中克隆并鉴定与带3相关的cDNA。
J Biol Chem. 1988 Nov 15;263(32):17092-9.
10
Band 3, the anion transporter, is conserved during evolution: implications for aging and vertebrate evolution.
Cell Mol Biol (Noisy-le-grand). 1995 Sep;41(6):833-42.

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本文引用的文献

1
Modification by papain of the structure and function of band 3, the erythrocyte anion transport protein.
Biochemistry. 1981 Dec 8;20(25):7118-23. doi: 10.1021/bi00528a011.
2
Synthesis of the erythrocyte anion-transport protein. Immunochemical study of its incorporation into the plasma membrane of erythroid cells.红细胞阴离子转运蛋白的合成。关于其整合到红细胞质膜的免疫化学研究。
Biochem J. 1981 Apr 1;195(1):129-37. doi: 10.1042/bj1950129.
3
Characterization and partial sequence of di-iodosulphophenyl isothiocyanate-binding peptide from human erythrocyte anion-transport protein.人红细胞阴离子转运蛋白中二碘硫代苯基异硫氰酸酯结合肽的表征及部分序列
Biochem J. 1982 Sep 1;205(3):465-75. doi: 10.1042/bj2050465.
4
The locations of the three cysteine residues in the primary structure of the intrinsic segments of band 3 protein, and implications concerning the arrangement of band 3 protein in the bilayer.带3蛋白内在片段一级结构中三个半胱氨酸残基的位置，以及关于带3蛋白在双层膜中排列的意义。
Biochim Biophys Acta. 1983 Mar 23;729(1):150-60. doi: 10.1016/0005-2736(83)90465-0.
5
Peptides of human erythrocyte band 3 protein produced by extracellular papain cleavage.细胞外木瓜蛋白酶切割产生的人红细胞带3蛋白的肽段。
J Biol Chem. 1984 Apr 10;259(7):4652-60.
6
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.真核生物mRNA翻译起始位点上游序列的汇编与分析。
Nucleic Acids Res. 1984 Jan 25;12(2):857-72. doi: 10.1093/nar/12.2.857.
7
The human erythrocyte anion-transport protein. Partial amino acid sequence, conformation and a possible molecular mechanism for anion exchange.人类红细胞阴离子转运蛋白。部分氨基酸序列、构象及阴离子交换的一种可能分子机制。
Biochem J. 1983 Sep 1;213(3):577-86. doi: 10.1042/bj2130577.
8
Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.缓冲液梯度凝胶和35S标记辅助快速DNA序列测定。
Proc Natl Acad Sci U S A. 1983 Jul;80(13):3963-5. doi: 10.1073/pnas.80.13.3963.
9
Rapid similarity searches of nucleic acid and protein data banks.核酸和蛋白质数据库的快速相似性搜索。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):726-30. doi: 10.1073/pnas.80.3.726.
10
Erythrocyte band 3 protein: evidence for multiple membrane-crossing segments in the 17 000-dalton chymotryptic fragment.红细胞带3蛋白：17000道尔顿胰凝乳蛋白酶片段中多个跨膜区段的证据。
Biochemistry. 1984 Dec 18;23(26):6432-6. doi: 10.1021/bi00321a024.