从cDNA序列推导的人红细胞膜阴离子转运蛋白的完整氨基酸序列。
The complete amino acid sequence of the human erythrocyte membrane anion-transport protein deduced from the cDNA sequence.
作者信息
Tanner M J, Martin P G, High S
机构信息
Department of Biochemistry, School of Medical Sciences, University of Bristol, U.K.
出版信息
Biochem J. 1988 Dec 15;256(3):703-12. doi: 10.1042/bj2560703.
Abstract
- We have isolated cDNA clones corresponding to the red cell membrane anion-transport protein (Band 3). 2. The cDNA clones cover 3475 bases of the mRNA and contain the entire protein-coding region, 150 bases of the 5' untranslated region and part of the 3' non-coding region, but do not extend to the 3' end of the mRNA. 3. The translated protein sequence predicts that the human red cell anion transporter contains 911 amino acids. 4. The availability of the amino acid sequence allows the interpretation of some of the many studies on the chemical and proteolytic modification of the human protein aimed at examining the structure and mechanism of this membrane transport protein.
摘要
- 我们已经分离出了与红细胞膜阴离子转运蛋白（带3）相对应的cDNA克隆。2. 这些cDNA克隆覆盖了mRNA的3475个碱基，包含整个蛋白质编码区、5'非翻译区的150个碱基以及3'非编码区的一部分，但并未延伸至mRNA的3'末端。3. 翻译后的蛋白质序列预测人类红细胞阴离子转运蛋白包含911个氨基酸。4. 氨基酸序列的可得性使得对旨在研究这种膜转运蛋白结构和机制的人类蛋白质化学及蛋白水解修饰的众多研究中的一些研究结果得以解读。
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本文引用的文献
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Modification by papain of the structure and function of band 3, the erythrocyte anion transport protein.
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Synthesis of the erythrocyte anion-transport protein. Immunochemical study of its incorporation into the plasma membrane of erythroid cells.红细胞阴离子转运蛋白的合成。关于其整合到红细胞质膜的免疫化学研究。
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Characterization and partial sequence of di-iodosulphophenyl isothiocyanate-binding peptide from human erythrocyte anion-transport protein.人红细胞阴离子转运蛋白中二碘硫代苯基异硫氰酸酯结合肽的表征及部分序列
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The locations of the three cysteine residues in the primary structure of the intrinsic segments of band 3 protein, and implications concerning the arrangement of band 3 protein in the bilayer.带3蛋白内在片段一级结构中三个半胱氨酸残基的位置，以及关于带3蛋白在双层膜中排列的意义。
Biochim Biophys Acta. 1983 Mar 23;729(1):150-60. doi: 10.1016/0005-2736(83)90465-0.
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