Clinical Psychologist, Institut Mutualiste Montsouris, Paris, France.
Department of Adolescent and Young Adult Psychiatry, Institut Mutualiste Montsouris, Paris, France.
Eat Weight Disord. 2021 Mar;26(2):709-715. doi: 10.1007/s40519-020-00893-9. Epub 2020 Apr 1.
Relationships between weight and fertility are well known. The aim of this study is to assess the prevalence of lifetime eating disorder (ED) in a sample of infertile women seeking a specific infertility treatment, pulsatile gonadotropin-releasing hormone (pGnRH) treatment, and to compare it to the prevalence of lifetime ED in a sample of infertile women seeking other types of assisted reproductive technology (ART) treatments.
Non-randomized, observational study including infertile female patients. Two-group design including consecutive women treated with GnRH pump (pGnRH) or with other types of ART.
Multi-centric infertility centers, France METHODS: Twenty one consecutive women treated with pGnRH treatment were compared to 21 consecutive women receiving other types of infertility treatment. Diagnosis of ED was based on DSM-IV and the Composite International Diagnostic Interview (CIDI).
Twenty patients (95.2%) from the sample of women treated with pulsatile GnRH treatment and 5 patients (23.8%) from the patients receiving other types of infertility treatment met the criteria of lifetime ED diagnosis (p < 0.000).
This study highlights the fact that the prevalence of ED is considerably higher in women receiving GnRH pulsatile treatment, when compared to women receiving other kinds of infertility treatment. In our study population ED were under-diagnosed, particularly in women receiving pulsatile GnRH treatment. Fertility clinicians should use reliable diagnostic tools to identify promptly ED in women presenting with hypothalamic amenorrhea and difficulties in conceiving. Level III: Evidence obtained from well-designed cohort or case-control analytic studies.
体重与生育力之间的关系众所周知。本研究旨在评估在寻求特定不孕治疗（脉冲式促性腺激素释放激素（pGnRH）治疗）的不孕女性样本中终生饮食障碍（ED）的患病率，并将其与寻求其他类型辅助生殖技术（ART）治疗的不孕女性样本中的终生 ED 患病率进行比较。
非随机、观察性研究，包括不孕女性患者。包括接受 GnRH 泵（pGnRH）治疗和接受其他类型 ART 治疗的连续女性患者的两组设计。
法国多中心不孕中心
将 21 例连续接受 pGnRH 治疗的女性与 21 例接受其他类型不孕治疗的女性进行比较。ED 的诊断基于 DSM-IV 和复合国际诊断访谈（CIDI）。
接受脉冲 GnRH 治疗的女性样本中有 20 例（95.2%）和接受其他类型不孕治疗的女性中有 5 例（23.8%）符合终生 ED 诊断标准（p<0.000）。
本研究强调了这样一个事实，即在接受 GnRH 脉冲治疗的女性中，ED 的患病率明显高于接受其他类型不孕治疗的女性。在我们的研究人群中，ED 的诊断不足，特别是在接受脉冲 GnRH 治疗的女性中。生育力临床医生应使用可靠的诊断工具，以便在出现下丘脑性闭经和受孕困难的女性中及时识别 ED。三级：从精心设计的队列或病例对照分析研究中获得的证据。
