Zerbinati Nicola, d'Este Edoardo, Farina Aurora, Cornaglia Antonia I, Jafferany Mohammad, Golubovic Masa, Binic Iva, Sigova Julia, Van Thuong Nguyen, Tirant Michael, Riva Federica, Protasoni Marina, Rauso Raffaele, Lotti Torello, Calligaro Alberto
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy.
Centro Medico Polispecialistico, Pavia, Italy.
Dermatol Ther. 2020 May;33(3):e13362. doi: 10.1111/dth.13362. Epub 2020 Apr 8.
In this study, the application of a recently introduced device based on electromagnetic energy transfer by microwaves for fat reduction, permitted to study specifically the modifications of thick fibrous collagen interlobular septa in the subcutaneous adipose tissue, related to the formation of large clusters of adipocytes. The use of Picrosirius red staining associated with circularly polarized microscopy gave evidence of appreciable modifications of the fibrous connective tissue forming septa. Compact fibrotic bundles of collagen I forming interlobular septa appeared reduced or dissolved, in part substituted by the increase of more diffuse and finely reticular collagen III. Remodeling of fibrous collagen, which formed bridles involved in the appearance at the surface of the skin of dimpling/orange peer pattern typical of cellulite, was observed.
在本研究中，应用一种最近推出的基于微波电磁能量传输的减脂设备，得以专门研究皮下脂肪组织中粗大纤维性胶原小叶间隔的改变，这些改变与大量脂肪细胞簇的形成有关。使用与圆偏振显微镜相关的天狼星红染色显示，构成间隔的纤维结缔组织有明显改变。形成小叶间隔的致密I型胶原纤维化束出现减少或溶解，部分被更弥漫且精细网状的III型胶原增加所替代。观察到形成束带的纤维性胶原重塑，这些束带与橘皮组织典型的皮肤表面出现酒窝/橘皮样外观有关。
