Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
College of Animal Sciences, Yangtze University, Jingzhou, Hubei, China.
Birth Defects Res. 2020 May;112(8):573-583. doi: 10.1002/bdr2.1678. Epub 2020 Apr 2.
Ethanamizuril, a new anticoccidial agent that belongs to triazine derivatives, has a broad and good anticoccidial activity. To evaluate the reproductive toxicity and teratogenic potential of ethanamizuril, different concentrations of ethanamizuril were administered to Sprague-Dawley rats by feeding diets containing 0, 2, 8, and 30 ppm, respectively. Each group consisting of 30 males and 30 females (F0) was treated with different concentrations of ethanamizuril through a 13-week period before mating and during mating, gestation, parturition and lactation. In the 30 ppm dose group, pup body weight on days 7 and 21 in F1 offspring and day 21 in the F2a offspring were significantly decreased. A limited teratogenicity study was performed in combination with the F1 generation of a two-generation reproduction study. F1 offspring of the reproduction study were mated after weaning of the F2a offspring. Pregnant female rats were subjected to cesarean section on gestational day 20 for teratogenic examination. No obvious body weights, fetal body lengths, tail lengths, litter weights, number of viable fetuses, external, skeletal, or visceral malformations in fetuses were noted in any groups in the teratogenic test, but ethanamizuril could be passed on to offspring through lactation.
依沙吖啶，一种新型抗球虫药，属于三嗪衍生物，具有广泛而良好的抗球虫活性。为了评估依沙吖啶的生殖毒性和致畸潜力，通过给含 0、2、8 和 30ppm 依沙吖啶的饲料喂养 Sprague-Dawley 大鼠，分别给予不同浓度的依沙吖啶。每组 30 只雄性和 30 只雌性（F0）在交配前和交配期间、妊娠、分娩和哺乳期分别用不同浓度的依沙吖啶处理 13 周。在 30ppm 剂量组，F1 代幼鼠第 7 天和第 21 天以及 F2a 代幼鼠第 21 天的体重显著降低。在与两代生殖研究的 F1 代相结合的有限致畸性研究中。生殖研究的 F1 后代在 F2a 后代断奶后交配。妊娠雌性大鼠在妊娠第 20 天进行剖腹产以进行致畸检查。在致畸试验的任何组中，均未观察到明显的体重、胎儿体长、尾长、窝重、活胎数、胎儿外部、骨骼或内脏畸形，但依沙吖啶可通过哺乳期传递给后代。
