新型抗球虫药-乙酰胺嗪的比格犬 90 天口服毒性研究。
Beagle dog 90-day oral toxicity study of a novel coccidiostat - ethanamizuril.
机构信息
Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture and Rural Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, People's Republic of China.
School of Biological Engineering, Wuhan Polytechnic, Wuhan, 430074, People's Republic of China.
出版信息
BMC Vet Res. 2020 Nov 17;16(1):444. doi: 10.1186/s12917-020-02655-2.
BACKGROUND
Triazine coccidiostats are widely used in chickens and turkeys for coccidiosis control. Ethanamizuril is a novel triazine compound that exhibits anticoccidial activity in poultry. This study was designed to evaluate the subchronic toxicity of ethanamizuril in beagle dogs at doses of 12, 60 or 300 mg/kg/day in diet for 90 days.
RESULTS
Ethanamizuril was well tolerated at low and middle dosages in beagle dogs, and no drug-related toxical effects were observaed in terms of survival, clinical observations, organs weight and damage in these dose groups. However, in high dose administration group, food consumption and histologic changes in kidneys were noticed in both sexes of beagle dog, although the renal lesions were finally resolved at the end of 4 weeks exposure of ethanamizuril.
CONCLUSIONS
No-observed-adverse-effect level (NOAEL) was considered for ethanamizuril at dose of 60 mg/kg/day in Beagle dog. This result added toxicity effects of ethanamizuril to the safety database, which might guide safely using of ethanamizuril as a novel coccidiostat.
背景
三嗪类球虫抑制剂被广泛用于鸡和火鸡的球虫病防治。乙酰胺嗪是一种新型三嗪化合物，对家禽具有抗球虫活性。本研究旨在评估乙酰胺嗪在犬中的亚慢性毒性，剂量分别为 12、60 或 300mg/kg/天，喂食 90 天。
结果
乙酰胺嗪在低、中剂量下在犬中耐受良好，在这些剂量组中，未观察到与药物相关的毒性作用，如存活率、临床观察、器官重量和损伤。然而，在高剂量组中，雌雄犬均出现摄食量减少和肾脏组织学改变，但在暴露于乙酰胺嗪 4 周结束时，肾脏病变最终得到解决。
结论
在犬中，乙酰胺嗪的无观察不良效应水平（NOAEL）被认为是 60mg/kg/天。该结果为乙酰胺嗪的安全性数据库增加了毒性作用信息，这可能有助于指导乙酰胺嗪作为一种新型球虫抑制剂的安全使用。
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