Giroud Sabine, Chiticariu-Durr Elena
Service de dermatologie, CHUV, 1011 Lausanne.
Rev Med Suisse. 2020 Apr 1;16(688):624-628.
Bullous pemphigoid is the most frequent autoimmune bullous dermatosis. Cases induced by immune checkpoint inhibitors have been described. This antitumor immunotherapy changed the treatment of several malignant tumors, especially melanoma and non-small cell lung-cancer. Nevertheless, immune adverse events are common. We present a case of bullous pemphigoid induced by pembrolizumab to illustrate the link between this disease and the treatment with immune checkpoint inhibitors.
大疱性类天疱疮是最常见的自身免疫性大疱性皮肤病。由免疫检查点抑制剂引起的病例已有报道。这种抗肿瘤免疫疗法改变了几种恶性肿瘤的治疗方式,尤其是黑色素瘤和非小细胞肺癌。然而,免疫相关不良事件很常见。我们报告一例由帕博利珠单抗引起的大疱性类天疱疮病例,以说明这种疾病与免疫检查点抑制剂治疗之间的联系。