Department of Neurosurgery, Shengzhou People's Hospital (The First Affiliated Hospital of Zhejiang University Shengzhou Branch), No. 666 Dangui Road, Shengzhou 312400, Zhejiang, China.
Department of Neurosurgery, Shengzhou People's Hospital (The First Affiliated Hospital of Zhejiang University Shengzhou Branch), No. 666 Dangui Road, Shengzhou 312400, Zhejiang, China.
Clin Chim Acta. 2020 Jul;506:166-171. doi: 10.1016/j.cca.2020.03.039. Epub 2020 Mar 30.
Serum glucose and potassium ratio (GPR) was recently found to be related to outcome of aneurysmal subarachnoid hemorrhage. This retrospectively study was to investigate the association of serum GPR with mortality in severe traumatic brain injury (sTBI).
Clinical data were retrospectively reviewed of isolated sTBI patients admitted within 12 h after trauma between January 2014 and January 2019. We analyzed relationships between admission serum GPR and post-traumatic 30-day mortality in addition to admission Glasgow coma scale (GCS) scores. Discriminative ability was evaluated using area under receiver operating characteristic curve (AUC).
A total of 146 patients, of whom 37 (25.3%) died within 30 days following trauma, were included. Admission serum GPR emerged as an independent predictor for 30-day mortality (odds ratio, 5.256; 95% confidence interval (CI), 1.111-14.856) and overall survival (hazard ratio, 4.822; 95% CI, 1.157-12.870), with an AUC of 0.777 (95% CI, 0.693-0.835), which was equivalent to that of GCS scores (AUC, 0.831; 95% CI, 0.760-0.888; P = 0.179). There was a significant correlation between admission serum GPR and GCS scores (r = 0.293).
Serum GPR in cases of sTBI is substantially associated with trauma severity and 30-day mortality. Therefore, the potential value of serum GPR for predicting short-term mortality of sTBI patients is favorable.
最近发现血清葡萄糖与钾比值（GPR）与蛛网膜下腔出血的预后有关。本回顾性研究旨在探讨血清 GPR 与严重创伤性脑损伤（sTBI）死亡率的关系。
回顾性分析 2014 年 1 月至 2019 年 1 月 12 小时内入院的单纯 sTBI 患者的临床资料。我们分析了入院时血清 GPR 与创伤后 30 天死亡率以及入院时格拉斯哥昏迷评分（GCS）之间的关系。采用受试者工作特征曲线下面积（AUC）评估判别能力。
共纳入 146 例患者，其中 37 例（25.3%）在创伤后 30 天内死亡。入院时血清 GPR 是 30 天死亡率的独立预测因素（优势比，5.256；95%置信区间[CI]，1.111-14.856）和总生存率（风险比，4.822；95%CI，1.157-12.870），AUC 为 0.777（95%CI，0.693-0.835），与 GCS 评分相当（AUC，0.831；95%CI，0.760-0.888；P=0.179）。入院时血清 GPR 与 GCS 评分呈显著相关（r=0.293）。
sTBI 患者入院时的血清 GPR 与创伤严重程度和 30 天死亡率密切相关。因此，血清 GPR 预测 sTBI 患者短期死亡率的潜在价值是有利的。
