Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada.
Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada.
Mol Cell Endocrinol. 2020 Jun 1;509:110800. doi: 10.1016/j.mce.2020.110800. Epub 2020 Mar 30.
Beginning with the discovery more than 35 years ago that oxygen chemoreceptors of the fish gill are enriched with serotonin, numerous studies have examined the importance of this, and other neuroendocrine factors in piscine chemoreceptor function, and in particular on the chemoreceptor-mediated reflex control of breathing. However, despite these studies, there is continued debate as to the role of neuroendocrine factors in the initiation or modulation of breathing during environmental disturbances or physical activity. In this review, we summarize the state-of-knowledge surrounding the neuroendocrine control of oxygen chemoreception in fish and the associated reflex adjustments to ventilation. We focus on neurohumoral substances that either are present in chemosensory cells or those that are localised elsewhere but have also been implicated in the direct control of breathing. These substances include serotonin, catecholamines (adrenaline and noradrenaline), acetylcholine, purines and gaseous neurotransmitters. Despite the growing indirect evidence for an involvement of these neuroendocrine factors in chemoreception and ventilatory control, direct evidence awaits the incorporation of novel methods currently under development.
从 35 多年前发现鱼类鳃部的氧感受器富含 5-羟色胺开始，许多研究已经检验了这种物质和其他神经内分泌因子在鱼类感受器功能中的重要性，特别是在感受器介导的呼吸反射控制方面。然而，尽管进行了这些研究，对于神经内分泌因子在环境干扰或体力活动期间呼吸的启动或调节中的作用仍存在持续的争论。在这篇综述中，我们总结了鱼类氧感受器神经内分泌控制的知识现状，以及与通气相关的反射调节。我们重点关注存在于化学感受器细胞中的神经递质物质，或者那些位于其他地方但也被牵连到直接呼吸控制中的神经递质物质。这些物质包括 5-羟色胺、儿茶酚胺（肾上腺素和去甲肾上腺素）、乙酰胆碱、嘌呤和气体神经递质。尽管越来越多的间接证据表明这些神经内分泌因子参与了化学感受和通气控制，但直接证据仍有待于目前正在开发的新方法的应用。
