Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China; Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Gene. 2020 Jun 20;744:144633. doi: 10.1016/j.gene.2020.144633. Epub 2020 Mar 30.
Several studies have examined the association between transforming growth factor-β (TGF-β) genetic polymorphisms and chronic obstructive pulmonary disease (COPD) risk, but the results remained inconclusive and controversial.
We aimed to examine the correlation between TGF-β genetic polymorphisms and COPD risk through a comprehensive meta-analysis. Additionally, changes in circulating TGF-β concentrations across genotypes of TGF-β genetic polymorphisms were analyzed.
Literature search, quality assessment, and data extraction were completed independently and in duplicate. Data are expressed in odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI).
A total of 12 articles, involving 14 independent studies and 7 170 participants, were meta-analyzed for the correlation of five polymorphisms (rs2241712, rs1800469, rs1982073, rs6957, and rs2241718) in TGF-β gene with COPD risk. Under the allele model, no statistical significance was observed for all polymorphisms associated with COPD risk. Subsidiary analyses indicated that country, COPD stage, and diagnosis of COPD were potential sources of between-study heterogeneity. Filled full plots revealed no missing studies for all studied polymorphisms, except rs1982073. Genotype-phenotype analyses showed that carriers of rs1800469 CT genotype had significantly higher concentrations of circulating TGF-β than those with CC genotype in COPD patients (WMD: 0.28 pg/ml, 95% CI: 0.01 to 0.56).
Our findings failed to support the candidacy of TGF-β gene in the development of COPD, whereas the contribution of TGF-β gene to COPD might be ethnicity- and stage-dependent.
多项研究已经探讨了转化生长因子-β（TGF-β）基因多态性与慢性阻塞性肺疾病（COPD）风险之间的关联，但结果仍不确定且存在争议。
我们旨在通过综合荟萃分析来研究 TGF-β基因多态性与 COPD 风险之间的相关性。此外，还分析了 TGF-β基因多态性不同基因型的循环 TGF-β浓度变化。
独立且重复地进行文献检索、质量评估和数据提取。数据以比值比（OR）或加权均数差（WMD）及其 95%置信区间（CI）表示。
对五项 TGF-β基因多态性（rs2241712、rs1800469、rs1982073、rs6957 和 rs2241718）与 COPD 风险相关性的 12 项研究进行了荟萃分析，这些研究共涉及 14 项独立研究和 7170 名参与者。在等位基因模型下，所有与 COPD 风险相关的多态性均无统计学意义。亚组分析表明，国家、COPD 分期和 COPD 的诊断是研究间异质性的潜在来源。填充完整图显示，除 rs1982073 外，所有研究的多态性均未发现缺失的研究。基因型-表型分析显示，在 COPD 患者中，rs1800469 CT 基因型的携带者的循环 TGF-β浓度明显高于 CC 基因型（WMD：0.28pg/ml，95%CI：0.01 至 0.56）。
我们的研究结果不支持 TGF-β基因在 COPD 发病机制中的候选作用，而 TGF-β基因对 COPD 的影响可能取决于种族和疾病分期。
