Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiao Tong University (SJTU), School of Medicine, Shanghai, 20025, China.
Lung. 2011 Jun;189(3):213-23. doi: 10.1007/s00408-011-9294-3. Epub 2011 May 10.
Abnormalities in the transforming growth factor-β(1) (TGF-β(1)) gene are thought to be linked to chronic obstructive pulmonary disease (COPD). We investigated the association between the single nuclear polymorphisms (SNPs) of TGF-β(1) and the risk of COPD in a case-control study and meta-analysis. We genotyped 160 cases and 177 control subjects in a local hospital using the Mass-Array(TM) Technology Platform and then tested the association of four SNPs in TGF-β(1) (rs6957, rs1800469, rs2241712, and rs2241718) with COPD. Plasma TGF-β(1) level measurement was performed later. A database covering all papers published up to October 30, 2010, was then reviewed. Statistical analysis was performed using Revman 5.0 and STATA 11.0 software. No association was found between TGF-β(1) gene SNPs and an increased risk of COPD in Asians. By meta-analysis, the link of two polymorphisms, rs1800469 and rs1982073, was investigated in seven and eight studies, respectively, involving 1,508 COPD patients and 2,608 control subjects. The results showed that there was no significant association between an increased risk of COPD in carriers of the T allele (TT+TC) versus the CC genotype in rs1800469 and rs1982073. In ethnic subgroup analysis, the risk of COPD associated with the rs1800469 T allele was not significantly elevated among Asians. TGF-β(1) gene polymorphisms are not associated with an increased risk of COPD in the Asian population.
转化生长因子-β(1)（TGF-β(1)）基因的异常与慢性阻塞性肺疾病（COPD）有关。我们通过病例对照研究和荟萃分析，研究了 TGF-β(1)的单核苷酸多态性（SNP）与 COPD 风险之间的关系。我们使用 Mass-Array(TM)技术平台对当地医院的 160 例病例和 177 例对照进行基因分型，然后检测了 TGF-β(1)中的四个 SNP(rs6957、rs1800469、rs2241712 和 rs2241718)与 COPD 的相关性。之后进行了 TGF-β(1)的血浆水平测量。然后，我们对截至 2010 年 10 月 30 日所有已发表文献的数据库进行了综述。统计分析使用 Revman 5.0 和 STATA 11.0 软件进行。在亚洲人群中，未发现 TGF-β(1)基因 SNP 与 COPD 风险增加之间存在关联。通过荟萃分析，研究了 rs1800469 和 rs1982073 两个多态性在七个和八个研究中的关联，分别涉及 1508 例 COPD 患者和 2608 例对照。结果表明，rs1800469 和 rs1982073 中携带 T 等位基因（TT+TC）的个体与 CC 基因型相比，COPD 风险无显著增加。在亚组分析中，rs1800469 T 等位基因与 COPD 的相关性在亚洲人群中也没有显著升高。TGF-β(1)基因多态性与亚洲人群 COPD 风险增加无关。
