Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Epilepsy Behav. 2020 May;106:107038. doi: 10.1016/j.yebeh.2020.107038. Epub 2020 Mar 30.
Patients with juvenile myoclonic epilepsy (JME) show evidence of cognitive impulsivity that may be linked to later adverse psychosocial outcomes. Here, we quantify the strength of association and estimate effect size (ES) of response inhibition by pooling available evidence in a meta-analysis.
We conducted a systematic review of the literature using Ovid MEDLINE and Ovid EMBASE databases (covering 2001-2019) with a search strategy using combinations of the specific Medical Subject Headings (MeSH) terms 'juvenile myoclonic epilepsy, cognitive impulsivity, response inhibition, Stroop, cognition, personality, traits' using the 'explode' feature where possible. We also searched within references of retrieved articles. We included studies reporting ESs describing established measures of response inhibition in teenage and adult patients with JME.
Using the ESs pooled from 16 studies comprising 1047 patients and controls, we found ESs for response inhibition to be homogeneous with a significant moderate mean ES of d = 0.50 (95% confidence interval [CI]: 0.37-0.63).
We confirm that reduced response inhibition is a consistently observed homogeneous trait in patients with JME.
青少年肌阵挛癫痫（JME）患者表现出认知冲动的证据，这可能与以后的不良社会心理结果有关。在这里，我们通过荟萃分析汇总可用证据来定量关联的强度，并估计反应抑制的效应大小（ES）。
我们使用 Ovid MEDLINE 和 Ovid EMBASE 数据库（涵盖 2001-2019 年）进行了系统的文献回顾，使用特定的医学主题词（MeSH）术语的组合进行搜索策略“青少年肌阵挛癫痫、认知冲动、反应抑制、斯特鲁普、认知、人格、特征”，尽可能使用“爆炸”功能。我们还在检索到的文章的参考文献中进行了搜索。我们纳入了报告描述 JME 青少年和成年患者中既定反应抑制测量的 ES 的研究。
使用来自 16 项研究的 1047 名患者和对照的 ES 进行汇总，我们发现反应抑制的 ES 具有同质的显著中等平均 ES 值 d=0.50（95%置信区间[CI]：0.37-0.63）。
我们证实，反应抑制降低是 JME 患者中一致观察到的同质特征。
