Section on Growth and Development, Eunice Kennedy ShriverNational Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
J Endocrinol. 2020 Jul;246(1):R1-R11. doi: 10.1530/JOE-20-0045.
The resting zone houses a group of slowly proliferating 'reserve' chondrocytes and has long been speculated to serve as the stem cell niche of the postnatal growth plate. But are these resting chondrocytes bona fide stem cells? Recent technological advances in lineage tracing and next-generation sequencing have finally allowed researchers to answer this question. Several recent studies have also shed light into the signaling pathways and molecular mechanisms involved in the maintenance of resting chondrocytes, thus providing us with important new insights into the role of the resting zone in the paracrine and endocrine regulation of childhood bone growth.
静止区容纳了一群增殖缓慢的“储备”软骨细胞，长期以来一直被推测为出生后生长板的干细胞龛。但是这些静止的软骨细胞是真正的干细胞吗？谱系追踪和下一代测序等技术的最新进展终于使研究人员能够回答这个问题。最近的几项研究还揭示了维持静止软骨细胞的信号通路和分子机制，从而为我们提供了关于静止区在儿童骨骼生长的旁分泌和内分泌调节中的作用的重要新见解。
