Allcock H R, Gebura M, Kwon S, Neenan T X
Department of Chemistry, Pennsylvania State University, University Park 16802.
Biomaterials. 1988 Nov;9(6):500-8. doi: 10.1016/0142-9612(88)90045-2.
The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH2CF3)x (NHCH3)y)]n and [NP(OC6H5)x (NHCH3)y]n, have been prepared by the sequential replacement of chlorine in [NPCI2]n by trifluorethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to gamma radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH2CF3)2]n, [NP(OC6H5)2]n, and [NP(NHCH3)2]n. The radiation-cross-linking and appeared to involve free radical reactions at the methyl groups of the methylamino substituents. The possible utility of these materials in biomedical research is discussed.
两亲性混合取代聚磷腈，即[NP(OCH2CF3)x (NHCH3)y]n和[NP(OC6H5)x (NHCH3)y]n，是通过用三氟乙氧基或苯氧基以及甲胺依次取代[NPCl2]n中的氯而制备的。将这些物质的薄膜暴露于γ辐射下进行交联，并监测所得膜的半透性。将这些聚合物的辐射诱导交联和成膜性能与单取代聚合物[NP(OCH2CF3)2]n、[NP(OC6H5)2]n和[NP(NHCH3)2]n的性能进行了比较。辐射交联似乎涉及甲氨基取代基甲基上的自由基反应。讨论了这些材料在生物医学研究中的可能用途。
