College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, 266003 Qingdao, China.
College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, 266003 Qingdao, China; Pilot National Laboratory for Marine Science and Technology, No.1 Wenhai Road, 266237 Qingdao, China.
Carbohydr Polym. 2020 Jun 1;237:116172. doi: 10.1016/j.carbpol.2020.116172. Epub 2020 Mar 19.
Albeit gelatin hard capsules were predominantly applied, their disadvantages call for endeavours on non-gelatin capsules in healthcare aspects. Herein, high molecular weight (Mw = 1 × 10) pullulan was purified from yeast fermentation broth. This high Mw pullulan and commercial low Mw pullulan were respectively co-blended with gellan to prepare the optimal solutions for capsule production. Further investigations, including loss-on-drying, brittleness and tightness, showed that the obtained pullulan-gellan capsules were of low water content, brittleness, leakage, and of high tightness. These capsules exhibited an extended release of amoxicillin over 60 min in simulated gastric fluid. Although the use of high and low Mw pullulan produced composite capsules with similar properties, the required concentration of high Mw pullulan was nearly half of that for low Mw pullulan, suggesting a cost-saving characteristic of using high Mw pullulan. This work proposes a potential substitution of gelatin with pullulan-gellan composites for preparing hard capsules.
尽管明胶硬胶囊被广泛应用，但它们也存在一些缺点，需要在医疗保健方面努力寻找非明胶胶囊的替代品。在此，我们从酵母发酵液中提取了高分子量（Mw=1×10）普鲁兰。该高 Mw 普鲁兰和商业低 Mw 普鲁兰分别与结冷胶共混，以制备用于胶囊生产的最佳溶液。进一步的研究，包括干燥失重、脆性和密封性，表明所得到的普鲁兰-结冷胶胶囊的水含量低、脆性大、泄漏率高、密封性好。这些胶囊在模拟胃液中表现出阿莫西林长达 60 分钟的缓释效果。尽管使用高 Mw 和低 Mw 普鲁兰制备了具有相似性能的复合胶囊，但高 Mw 普鲁兰的所需浓度几乎是低 Mw 普鲁兰的一半，这表明使用高 Mw 普鲁兰具有节省成本的特点。这项工作提出了用普鲁兰-结冷胶复合材料替代明胶来制备硬胶囊的可能性。
