Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.
Department of Gastroenterology, Ascension Providence Hospital, Southfield, MI, USA.
Arab J Gastroenterol. 2020 Mar;21(1):9-18. doi: 10.1016/j.ajg.2020.01.004. Epub 2020 Mar 30.
It has been suggested that smoking may be associated with microscopic colitis (MC) in some studies; however, there are conflicting results in the current literature with many of these studies having significant limitations. Our study aims to offer a meta-analysis evaluating the association between MC, including both its subtypes, and smoking.
A systemic review was conducted in PUBMED, Embase, PubMed Central, and ScienceDirect databases from inception through December 2019. Effect estimates from the individual studies were extracted and combined using the random effect, generic inverse variance method of DerSimonian and Laird and a pooled odds ratio (OR) was calculated. Forest plots were generated, and publication bias was assessed for using conventional techniques.
Eight observation studies with a total of 1461 patients with MC were included in this study, 383 of whom were active smokers (26.2%). Current smoking was significantly associated with MC (OR 3.58, 95% CI, 2.51-5.11), lymphocytic colitis (LC) (OR 3.64, 95% CI, 2.46-5.38), and collagenous colitis (CC) (OR 4.43, 95% CI, 2.68-7.32). Gender-specific subgroup analysis showed a significant association with smoking was found for CC in men (OR 4.53, 95% CI, 1.59-12.85), CC in women (OR 3.27, 95% CI, 2.35-4.54), LC in women (OR 2.27, 95% CI, 1.27-4.06) and MC in women (OR 2.93, 95% CI, 2.09-4.10). We found no publication bias as assessed by the funnel plots and Egger's regression asymmetry test.
Our meta-analysis found a statistically significant association between smoking and both subtypes of MC.
一些研究表明，吸烟可能与显微镜结肠炎（MC）有关；然而，目前的文献中存在相互矛盾的结果，其中许多研究存在显著的局限性。我们的研究旨在进行一项荟萃分析，评估 MC（包括其两个亚型）与吸烟之间的关联。
系统检索了 PUBMED、Embase、PubMed Central 和 ScienceDirect 数据库，检索时间从建库至 2019 年 12 月。提取各研究的效应估计值，并使用 DerSimonian 和 Laird 的随机效应、通用倒数方差法进行合并，计算合并优势比（OR）。生成森林图，并使用常规技术评估发表偏倚。
本研究共纳入 8 项观察性研究，共纳入 1461 例 MC 患者，其中 383 例为现患吸烟者（26.2%）。当前吸烟与 MC（OR 3.58，95%CI，2.51-5.11）、淋巴细胞性结肠炎（LC）（OR 3.64，95%CI，2.46-5.38）和胶原性结肠炎（CC）（OR 4.43，95%CI，2.68-7.32）显著相关。性别特异性亚组分析显示，男性 CC 与吸烟显著相关（OR 4.53，95%CI，1.59-12.85）、女性 CC（OR 3.27，95%CI，2.35-4.54）、女性 LC（OR 2.27，95%CI，1.27-4.06）和女性 MC（OR 2.93，95%CI，2.09-4.10）。漏斗图和 Egger 回归不对称检验未发现发表偏倚。
本荟萃分析发现吸烟与 MC 的两个亚型之间存在统计学显著关联。
