Department of Pathology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Department of General Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
J Endocrinol Invest. 2020 Nov;43(11):1571-1576. doi: 10.1007/s40618-020-01239-z. Epub 2020 Apr 2.
A reticulin staining pattern (RSP) can be used for the differential diagnosis of endocrine gland lesions, as in the adrenal and hypophysis glands. We aimed to use RSP for the differential diagnosis of parathyroid gland lesions.
In this study, we evaluated 97 parathyroid lesions in 85 patients, as well as 29 normal parathyroid glands. All sections were stained with a silver impregnation-based kit for the reticulin stain. The RSPs were classified as short thick fiber-, anastomosing- and nodular/alveolar-pattern. The dominant pattern was accepted as being greater than 50% in each section.
Short thick fibers and anastomosing and nodular RSPs were seen in adenomas, but there was no alveolar pattern. Although nodular/alveolar patterns were seen in focal areas in hyperplasia, they never became the dominant pattern. Nodular dominant RSPs were seen in adenomas; however, nodular RSPs were not seen in hyperplasia in a dominant pattern (p = 0.049). While short thick fibers were not seen in normal glands, they could be seen in adenomas (p < 0.001) and in hyperplasia (p < 0.001).
RSPs can be used in the differential diagnosis of parathyroid lesions. While short thick reticular fibers support adenomas and hyperplasia rather than normal tissue, a nodular dominant pattern supports adenomas rather than hyperplasia.
网状纤维染色模式 (RSP) 可用于内分泌腺病变的鉴别诊断，如肾上腺和垂体。我们旨在使用 RSP 对甲状旁腺病变进行鉴别诊断。
本研究评估了 85 例患者的 97 个甲状旁腺病变和 29 个正常甲状旁腺。所有切片均用基于银浸染的网状纤维染色试剂盒进行染色。RSP 分为短厚纤维型、吻合型和结节/肺泡型。在每个切片中，占主导地位的模式被认为大于 50%。
腺瘤中可见短厚纤维和吻合及结节 RSP，但无肺泡模式。虽然增生中可见局灶性结节/肺泡模式，但从未成为主导模式。结节为主的 RSP 见于腺瘤，但增生中未见结节为主的 RSP（p=0.049）。短厚纤维在正常腺体中未见，但在腺瘤（p<0.001）和增生（p<0.001）中可见。
RSP 可用于甲状旁腺病变的鉴别诊断。短厚网状纤维支持腺瘤和增生而非正常组织，而结节为主的模式支持腺瘤而非增生。
