King D T, Hirose F M
Arch Pathol Lab Med. 1979 Nov;103(12):609-12.
The chief cells of parathyroid adenomas were found to contain less intracytoplasmic fat than normal parathyroid glands and/or the adjacent rims of nonadenomatous parathyroid tissue. The amount of sudanophilic material in the chief cells was relatively uniform for each individual adenoma, but varied between patients. In half of the patients with parathyroid adenomas, Sudan-positive granules were generally absent from the adenomatous cells, whereas in the other half the granules were easily identifiable. The chief cells of secondary hyperplasia showed a less uniform pattern in each gland. In some areas, the stain for intracellular fat was negative, while adjacent cells contained prominent Sudan-positive granules. These findings suggest that staining frozen sections for intracellular fat is a useful but limited aid in the differentiation of parathyroid adenomas from normal parathyroid gland tissue.
甲状旁腺腺瘤的主细胞被发现比正常甲状旁腺和/或非腺瘤性甲状旁腺组织的相邻边缘含有更少的胞浆内脂肪。每个单独的腺瘤中主细胞内嗜苏丹物质的量相对一致，但患者之间有所不同。在一半的甲状旁腺腺瘤患者中，腺瘤细胞通常没有苏丹阳性颗粒，而在另一半患者中，颗粒很容易识别。继发性增生的主细胞在每个腺体中显示出不太一致的模式。在一些区域，细胞内脂肪染色为阴性，而相邻细胞含有明显的苏丹阳性颗粒。这些发现表明，对细胞内脂肪进行冰冻切片染色在区分甲状旁腺腺瘤与正常甲状旁腺组织方面是一种有用但有限的辅助手段。
