甲状旁腺肿瘤鉴别诊断中的网状纤维结构。

Reticular fibre structure in the differential diagnosis of parathyroid neoplasms.

机构信息

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Department of Pathology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.

出版信息

Diagn Pathol. 2023 Jul 4;18(1):79. doi: 10.1186/s13000-023-01368-y.

DOI:10.1186/s13000-023-01368-y

PMID:37403167

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10318729/

Abstract

BACKGROUND

To investigate the characteristics of reticular fibre structure (RFS) in parathyroid adenoma (PTA), atypical parathyroid tumour (APT), and parathyroid carcinoma (PTC), and to assess its value as a diagnostic indicator.

METHODS

Clinical data and pathological specimens of patients with PTA, APT or PTC were collected. Reticular fibre staining was performed to observe the characteristics of RFS. This study evaluated the incidence of RFS destruction in parathyroid tumours, compared RFS destruction between primary PTC and recurrent and metastatic PTC, and explored the association between RFS destruction and clinicopathological features of APT and primary PTC.

RESULTS

Reticular fibre staining was performed in 50 patients with PTA, 25 patients with APT, and 36 patients with PTC. In PTA cases, a delicate RFS was observed. In both the APT and PTC groups, incomplete RFS areas were observed. The incidence of RFS destruction was different among the PTA, APT, and PTC groups (P < 0.001, χ-test), at 0% (0/50), 44% (11/25), and 86% (31/36), respectively. When differentiating PTC from APT, the sensitivity and specificity of RFS destruction were 81% and 56%, respectively. The incidence of RFS destruction was 73% (8/11) in the primary PTC group and 92% (23/25) in the recurrent and metastatic PTC groups. In both the APT group and primary PTC group, no correlation was found between RFS destruction and clinicopathological features.

CONCLUSION

RFS destruction may indicate that parathyroid tumours have unfavourable biological behaviours.Reticular fibre staining may be a valuable tool for improving the diagnostic accuracy in parathyroid tumours.

摘要

背景

为了研究甲状旁腺腺瘤（PTA）、非典型甲状旁腺肿瘤（APT）和甲状旁腺癌（PTC）中网状纤维结构（RFS）的特征，并评估其作为诊断指标的价值。

方法

收集 PTA、APT 或 PTC 患者的临床资料和病理标本。进行网状纤维染色，观察 RFS 的特征。本研究评估了 RFS 破坏在甲状旁腺肿瘤中的发生率，比较了原发性 PTC 和复发性、转移性 PTC 中 RFS 破坏的差异，并探讨了 RFS 破坏与 APT 和原发性 PTC 的临床病理特征之间的关系。

结果

对 50 例 PTA、25 例 APT 和 36 例 PTC 患者进行了网状纤维染色。在 PTA 病例中，观察到精细的 RFS。在 APT 和 PTC 组中，观察到不完全的 RFS 区域。PTA、APT 和 PTC 组之间 RFS 破坏的发生率不同（P<0.001，χ 检验），分别为 0%（0/50）、44%（11/25）和 86%（31/36）。在区分 PTC 和 APT 时，RFS 破坏的敏感性和特异性分别为 81%和 56%。原发性 PTC 组 RFS 破坏的发生率为 73%（8/11），复发性、转移性 PTC 组为 92%（23/25）。在 APT 组和原发性 PTC 组中，RFS 破坏与临床病理特征均无相关性。